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  4. DHX32 Antibody

DHX32 Antibody

  • 中文名称：
    DHX32兔多克隆抗体
  • 货号：
    CSB-PA006874GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q7L7V1
  • 基因名：
    DHX32
  • 别名：
    3110079L04Rik antibody; AA408140 antibody; Ddx32 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32 antibody; DEAD/H box 32 antibody; DEAD/H helicase like protein 1 antibody; DEAD/H helicase-like protein 1 antibody; DEAH (Asp-Glu-Ala-His) box polypeptide 32 antibody; DEAH box protein 32 antibody; DHLP1 antibody; DHX32 antibody; DHX32_HUMAN antibody; Helicase DDX32 antibody; HuDDX32 antibody; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DHX32
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. DHX32 is an upstream regulator for beta-catenin, which promotes the activity of beta-catenin to upregulate expression of VEGFA in colorectal cancer cells. Depletion of DHX32 expression suppressed colorectal cancer tumor angiogenesis and tumor growth. PMID: 28330603
    2. Structural characterization and expression of the DDX32 gene. Expression studies show that DDX32 is widespread but specifically down-regulated in acute lymphoblastic leukemias and might play a role in normal and/or abnormal lymphopoiesis. PMID: 12163057
    3. cloned DHX32 proximal promoter and identified a 218bp fragment containing two potential binding sites for the transcription factor nuclear factor of activated T cells (NF-AT) PMID: 16414036
    4. These results suggest that DHX32 is a putative RNA helicase that might be involved in regulating nuclear and mitochondrial gene expression. PMID: 16959245
    5. dysregulated expression of DHX32 might lead to as of yet unknown changes in mitochondrial homeostasis manifested by cytoplasmic redistribution of the molecular chaperon Hsp60 PMID: 17174952
    6. In peripheral blood lymphocytes, a correlation between DHX32 and c-FLIP short expression was detected in response to different T-cell activation stimuli. Results suggest DHX32 involvement in regulating T-cell response to apoptotic stimuli. PMID: 17352256
    7. DHX32 may play an important role in the development of colorectal cancer and could serve as a novel biomarker for colorectal cancer after additional investigation. PMID: 19161603

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  • 亚细胞定位：
    Nucleus. Mitochondrion.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily
  • 组织特异性：
    Expressed in lymphoid tissues (at protein level). Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, lymphoid tissues and blood leukocytes.
  • 数据库链接：

    HGNC: 16717

    OMIM: 607960

    KEGG: hsa:55760

    STRING: 9606.ENSP00000284690

    UniGene: Hs.370292