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DISP1 Antibody

  • 中文名称：
    DISP1兔多克隆抗体
  • 货号：
    CSB-PA006916GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96F81
  • 基因名：
    DISP1
  • 别名：
    DISP 1 antibody; disp1 antibody; DISP1_HUMAN antibody; DISPA antibody; Dispatched A antibody; Dispatched homolog 1 antibody; DKFZP434I0428 antibody; FLJ43740 antibody; MGC104180 antibody; MGC13130 antibody; MGC16796 antibody; Protein dispatched homolog 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human DISP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion.
  • 基因功能参考文献：
    1. The top single-nucleotide polymorphism (SNP) was rs17162912 (P=1.76 x 10(-8)), which is near the DISP1 gene on 1q41-q42, a microdeletion region implicated in neurological development. PMID: 25824302
    2. DISP-1 is required for non-small cell lung carcinoma cells proliferation PMID: 22733134
    3. Studies indicate that DISP1 haploinsufficiency may not be solely responsible for the major features of 1q41q42 microdeletion syndrome, and other genes in the SRO likely play a role in the phenotype. PMID: 20951845
    4. report of 1st de novo DISP1 point mutation in patient with congenital diaphragmatic hernia (CDH); finding with Disp1 embryonic mouse diaphragm and lung expression and previously reported 1q41q42 aberrations in CDH suggests DISP1 may be CDH candidate gene PMID: 20799323
    5. describe two independent families with truncating mutations in DISP1 that resemble the cardinal craniofacial and neuro-developmental features of a recently described microdeletion syndrome that includes this gene PMID: 19184110

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Dispatched family
  • 数据库链接：

    HGNC: 19711

    OMIM: 607502

    KEGG: hsa:84976

    STRING: 9606.ENSP00000284476

    UniGene: Hs.528817