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DNAI1 Antibody

  • 货号：
    CSB-PA008835
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UI46
  • 基因名：
    DNAI1
  • 别名：
    Axonemal dynein intermediate chain 1 antibody; Axonemal dynein intermediate chain 2 antibody; CILD 1 antibody; CILD1 antibody; Cytoplasmic dynein 1 intermediate chain 1 antibody; Cytoplasmic dynein 1 intermediate chain 2 antibody; Cytoplasmic dynein intermediate chain 1 antibody; Cytoplasmic dynein intermediate chain 2 antibody; DH IC 1 antibody; DH IC 2 antibody; DIC1 antibody; DNAI 1 antibody; DNAI 2 antibody; DNAI1 antibody; DNAI1_HUMAN antibody; DNAI2 antibody; DNCI 2 antibody; DNCI1 antibody; DNCI2 antibody; DNCIC 1 antibody; DNCIC 2 antibody; DNCIC1 antibody; DNCIC2 antibody; Dynein axonemal intermediate chain 1 antibody; Dynein axonemal intermediate polypeptide 1 antibody; Dynein axonemal intermediate polypeptide 2 antibody; Dynein cytoplasmic intermediate polypeptide 1 antibody; Dynein cytoplasmic intermediate polypeptide 2 antibody; Dynein intermediate chain 1 axonemal antibody; Dynein intermediate chain 1 cytosolic antibody; Dynein intermediate chain 1; axonemal antibody; Dynein intermediate chain 2 axonemal antibody; Dynein intermediate chain 2 cytosolic antibody; Dynein intermediate chain DNAI1 antibody; IC74 antibody; ICS antibody; ICS1 antibody; Immotile cilia syndrome 1 antibody; MGC26204 antibody; PCD antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Dynein IC1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of the dynein complex of respiratory cilia.
  • 基因功能参考文献：
    1. A novel mutation causing primary ciliary dyskinesia was found in Japanese patients. PMID: 28939216
    2. The worldwide involvement of DNAI1 mutations in PCD pathogenesis in families not preselected for ODA defects ranges from 7 to 10%. PMID: 21143860
    3. A total of 10% of patients with PCD are estimated to harbor mutations in DNAI1; most occur as a common founder IVS1+2_3insT or in exons 13, 16, and 17. PMID: 16858015
    4. DNAI1 gene mutation is not a common cause of primary ciliary dyskinesia. PMID: 18434704
    5. Two dynein genes, encoding ODA intermediate chain (DNAI1) and heavy chain (DNAH5), have been seen to be mutated in approximately 30-38% of the families PMID: 19300264

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  • 相关疾病：
    Ciliary dyskinesia, primary, 1 (CILD1); Kartagener syndrome (KTGS)
  • 亚细胞定位：
    Dynein axonemal particle. Cytoplasm, cytoskeleton, cilium axoneme.
  • 蛋白家族：
    Dynein intermediate chain family
  • 组织特异性：
    Expressed in respiratory ciliated cells (at protein level).
  • 数据库链接：

    HGNC: 2954

    OMIM: 244400

    KEGG: hsa:27019

    STRING: 9606.ENSP00000242317

    UniGene: Hs.112667