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Dll Antibody

  • 货号：
    CSB-PA322586XA01DLU
  • 规格：
    ￥880
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:Dll Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 17.8 kDa
      Observed band size: 18 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Drosophila melanogaster (Fruit fly) Dll Antibody Polyclonal antibody
  • Uniprot No.：
    P20009
  • 基因名：
    Dll Antibody
  • 别名：
    Homeotic protein distal-less (Protein brista) Dll Ba BR CG3629
  • 宿主：
    Rabbit
  • 反应种属：
    Drosophila melanogaster (Fruit fly)
  • 免疫原：
    Recombinant Drosophila melanogaster (Fruit fly) Dll protein (30-170aa)
  • 免疫原种属：
    Drosophila melanogaster (Fruit fly)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a role in larval and adult appendage development. Specifies the identity of ventral appendages (including legs and antennae) and suppresses dorsal appendage development. Involved in patterning the distal-proximal limb axis. May control the adhesive properties of cells during limb morphogenesis. Also has a secondary role in the normal patterning of the wing margin.
  • 基因功能参考文献：
    1. Characterization of Dll expression in the developing nervous system supports a role of Dll in neural development and function PMID: 26472170
    2. Distal-less regulatory element that controls gene expression in leg precursor cells recruits multiple Hox, Extradenticle (Exd) and Homothorax (Hth) complexes to mediate dual outputs: thoracic activation and abdominal repression. PMID: 27058369
    3. Joint ectopic expression of Dll and Rn is sufficient to cell-autonomously activate endogenous bab2 and LAE-driven reporter expression in wing and haltere cells PMID: 23825964
    4. findings show a spot of dark pigment on fly wings emerged from assembly of a novel gene regulatory module in which a set of pigmentation genes evolved to respond to a common transcriptional regulator determining their spatial distribution; the primitive wing spot pattern subsequently diversified through changes in expression pattern of this regulator PMID: 23520110
    5. Hox proteins regulate Dll transcription in part by locally modifying chromatin structure at the Dll locus. PMID: 22523743
    6. studied a 17kb genomic region in the Dll locus which lies downstream of the coding sequence and found control elements of primary functional importance for the expression of Dll in the leg and in other tissues PMID: 21320482
    7. The medial leg fates are established via a regulatory cascade in which Wg+Dpp activate Distalless and then Distalless directly activates dac, with Wg+Dpp as less critical, permissive inputs. PMID: 21497759
    8. disco plays a fundamental role in the Dll-dependent patterning of antenna and leg, perhaps as a regulator of Dll gene expression PMID: 19756755
    9. Distal-less...specify antenna fates via regulation of multiple genes. PMID: 11934862
    10. Hox protein Ultrabithorax (Ubx) suppresses limb formation in the abdomen by repressing the leg selector gene Distalless PMID: 12408801
    11. Dll functions in subdividing the thoracic limb primordium. PMID: 15712199
    12. These findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll. PMID: 19036798

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the embryo in limb primordia of the head and thoracic segments. Expressed in regions of the larval leg, wing, antennal and haltere disks that form the distal-most regions of the mature structures (in the leg this corresponds to the tarsus and
  • 数据库链接：

    KEGG: dme:Dmel_CG3629

    UniGene: Dm.7063