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  4. Recombinant Drosophila melanogaster Homeotic protein distal-less (Dll)

Recombinant Drosophila melanogaster Homeotic protein distal-less (Dll)

  • 货号：
    CSB-YP322586DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP322586DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP322586DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP322586DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP322586DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dll
  • Uniprot No.：
  • 别名：
    Dll; Ba; BR; CG3629Homeotic protein distal-less; Protein brista
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-327
  • 氨基酸序列
    MDAPDAPHTP KYMDGGNTAA SVTPGINIPG KSAFVELQQH AAAGYGGIRS TYQHFGPQGG QDSGFPSPRS ALGYPFPPMH QNSYSGYHLG SYAPPCASPP KDDFSISDKC EDSGLRVNGK GKKMRKPRTI YSSLQLQQLN RRFQRTQYLA LPERAELAAS LGLTQTQVKI WFQNRRSKYK KMMKAAQGPG TNSGMPLGGG GPNPGQHSPN QMHSGGNNGG GSNSGSPSHY LPPGHSPTPS STPVSELSPE FPPTGLSPPT QAPWDQKPHW IDHKPPPQMT PQPPHPAATL HPQTHHHNPP PQMGGYVPQY WYQPETNPSL VTVWPAV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a role in larval and adult appendage development. Specifies the identity of ventral appendages (including legs and antennae) and suppresses dorsal appendage development. Involved in patterning the distal-proximal limb axis. May control the adhesive properties of cells during limb morphogenesis. Also has a secondary role in the normal patterning of the wing margin.
  • 基因功能参考文献：
    1. Characterization of Dll expression in the developing nervous system supports a role of Dll in neural development and function PMID: 26472170
    2. Distal-less regulatory element that controls gene expression in leg precursor cells recruits multiple Hox, Extradenticle (Exd) and Homothorax (Hth) complexes to mediate dual outputs: thoracic activation and abdominal repression. PMID: 27058369
    3. Joint ectopic expression of Dll and Rn is sufficient to cell-autonomously activate endogenous bab2 and LAE-driven reporter expression in wing and haltere cells PMID: 23825964
    4. findings show a spot of dark pigment on fly wings emerged from assembly of a novel gene regulatory module in which a set of pigmentation genes evolved to respond to a common transcriptional regulator determining their spatial distribution; the primitive wing spot pattern subsequently diversified through changes in expression pattern of this regulator PMID: 23520110
    5. Hox proteins regulate Dll transcription in part by locally modifying chromatin structure at the Dll locus. PMID: 22523743
    6. studied a 17kb genomic region in the Dll locus which lies downstream of the coding sequence and found control elements of primary functional importance for the expression of Dll in the leg and in other tissues PMID: 21320482
    7. The medial leg fates are established via a regulatory cascade in which Wg+Dpp activate Distalless and then Distalless directly activates dac, with Wg+Dpp as less critical, permissive inputs. PMID: 21497759
    8. disco plays a fundamental role in the Dll-dependent patterning of antenna and leg, perhaps as a regulator of Dll gene expression PMID: 19756755
    9. Distal-less...specify antenna fates via regulation of multiple genes. PMID: 11934862
    10. Hox protein Ultrabithorax (Ubx) suppresses limb formation in the abdomen by repressing the leg selector gene Distalless PMID: 12408801
    11. Dll functions in subdividing the thoracic limb primordium. PMID: 15712199
    12. These findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll. PMID: 19036798

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the embryo in limb primordia of the head and thoracic segments. Expressed in regions of the larval leg, wing, antennal and haltere disks that form the distal-most regions of the mature structures (in the leg this corresponds to the tarsus and
  • 数据库链接：

    KEGG: dme:Dmel_CG3629

    UniGene: Dm.7063