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EAF2 Antibody

  • 货号：
    CSB-PA856910DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA856910DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA856910DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EAF2 Polyclonal antibody
  • Uniprot No.：
    Q96CJ1
  • 基因名：
    EAF2
  • 别名：
    BM 040 antibody; BM040 antibody; EAF 2 antibody; EAF2 antibody; EAF2_HUMAN antibody; Ehrlich S II transcriptional activator factor antibody; ELL associated factor 2 antibody; ELL-associated factor 2 antibody; Festa antibody; Testosterone regulated apoptosis inducer and tumor suppressor antibody; Testosterone regulated apoptosis inducer and tumor suppressor protein antibody; Testosterone-regulated apoptosis inducer and tumor suppressor protein antibody; TRAITS antibody; U19 antibody; Uncharacterized bone marrow protein BM 040 antibody; Uncharacterized bone marrow protein BM040 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ELL-associated factor 2 protein (1-170AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional transactivator of TCEA1 elongation activity. Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
  • 基因功能参考文献：
    1. Simultaneous inactivation of EAF2 and p53 can act to activate STAT3 and drive prostate tumorigenesis. PMID: 29518696
    2. The results indicated that Eaf2 was able to effectively suppress H2O2induced apoptosis of HLE cells via inhibition of caspase 3 production and activation of Wnt3a signaling. PMID: 29257273
    3. EZH2 promotes tumorigenesis and malignant progression in part by activating glycolysis through an EAF2-HIF1alpha signaling axis. PMID: 27259264
    4. Concurrent p53 nuclear staining and EAF2 downregulation was associated with high Gleason score In human prostate cancer specimens. PMID: 29029019
    5. analysis showed that EAF2 and EAF1 are required for the recruitment and retention of Ku70/Ku80 to DNA damage sites and play a functional role in nonhomologous end-joining DNA repair. Findings provide evidence for EAF2 as a key factor mediating androgen protection of DNA damage via Ku70/Ku80 in prostate cancer cells. PMID: 27721405
    6. EAF2 binding does not alter Smad3 phosphorylation but causes Smad3 cytoplasmic retention, competes with Smad4 for binding to Smad3, and prevents p300-Smad3 complex formation PMID: 26370086
    7. Findings suggest that regulation of the AR signaling pathway, cell proliferation, and migration through FOXA1 represents an important mechanism of EAF2 suppression of prostate carcinogenesis. PMID: 25808853
    8. Together these findings identify a novel physical and functional interaction between EAF2 and the Rb pathway. PMID: 24727455
    9. EAF2 bound to and suppressed HIF-1alpha. PMID: 24421387
    10. the role of the EAF2 in response to simvastatin and lovastatin in HCT-116 colon cancer cells PMID: 21483694
    11. Data suggest that U19/EAF2 regulates the expression of TSP-1 via blocking p53 repression of the TSP-1 promoter. PMID: 19826414
    12. U19 is growth inhibitory and tumor suppressive and that the disruption of androgen-dependent growth inhibition via U19 down-regulation is commonly associated with prostate cancer progression. PMID: 12907652
    13. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. PMID: 16006523
    14. ELL may be an important factor required for U19/Eaf2 function because U19/Eaf2 nuclear localization and transactivation activity are essential for its function as a transcription factor. PMID: 16114057
    15. FB1 is an important binding partner and a functional regulator of U19/EAF2, EAF1, and/or ELL. PMID: 17395368

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  • 亚细胞定位：
    Nucleus speckle.
  • 蛋白家族：
    EAF family
  • 组织特异性：
    Expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymph node, spinal gland, stomach, thyroid, trachea, thymus, liver and leukocytes.
  • 数据库链接：

    HGNC: 23115

    OMIM: 607659

    KEGG: hsa:55840

    STRING: 9606.ENSP00000273668

    UniGene: Hs.477325