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EIF5A2 Antibody

  • 货号：
    CSB-PA002312
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using eIF5A2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9GZV4
  • 基因名：
    EIF5A2
  • 别名：
    9630038B20 antibody; eIF 5A 2 antibody; eIF 5A2 antibody; eIF-4D antibody; eIF-5A-2 antibody; eIF-5A2 antibody; EIF5A 2 antibody; EIF5A2 antibody; eIF5AII antibody; Eukaryotic initiation factor 5A isoform 2 antibody; Eukaryotic translation initiation factor 5A-2 antibody; Eukaryotic translation initiation factor 5A2 antibody; IF5A2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human eIF5A2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.
  • 基因功能参考文献：
    1. EIF5A2 as a direct and functional target of miR-203. PMID: 27376958
    2. The model had 92% sensitivity and 92% specificity. We obtained similar results in the independent validation cohort. AIB1 and EIF5A2 show promise for the noninvasive detection of bladder cancer. The model based on AIB1, EIF5A2, and NMP22 outperformed each of the three individual biomarkers for detecting Bladder cancer. PMID: 27203388
    3. Data suggest that inhibition of eIF5A2 alters progression of the EMT to decrease the invasion and metastasis of HCC cells via ROS-related pathways. PMID: 27028999
    4. EIF5A2 overexpression may contribute to cancer progression and poor prognosis. Therefore, EIF5A2 could be a novel potential prognostic marker for Federation of Gynecology and Obstetrics (FIGO) stage I-II cervical cancer. PMID: 26799253
    5. High EIF5A2 expression is associated with hepatocellular carcinoma. PMID: 27879277
    6. MiR-30b suppresses tumor migration and invasion by targeting EIF5A2 expression in gastric cancer cells. PMID: 26309359
    7. eIF-5A2 plays an important role in doxorubicin chemoresistance in breast cancer cells. PMID: 24638963
    8. Data indicate that regulation of sonic hedgehog (SHh)-GLI family zinc finger 1 (Gli1) signals to migration of pancreatic cancer AsPC-1 Cells through mediating eukaryotic translation initiation factor 5A (EIF5A2) gene expression. PMID: 26465952
    9. Data suggest that eukaryotic translation initiation factor 5A2 (EIF5A2) inhibitors might be considered as combination therapy to enhance chemosensitivity in patients with esophageal squamous cell carcinoma (ESCC). PMID: 26317793
    10. Our findings indicate that EIF5A2 upregulation plays an important oncogenic role in gastric cancer. EIF5A2 may represent a new predictor for poor survival and is a potential therapeutic target for gastric cancer. PMID: 25793713
    11. Increased expression of eIF5A2 increases metastasis and angiogenesis in esophageal squamous cell carcinoma via the HIF1alpha-mediated signaling pathway. PMID: 24561231
    12. focus on updating current knowledge of the EIF5A2 gene in human cancers PMID: 24250246
    13. EIF5A2 elevated TGF-beta1 expression through STAT3 to induce epithelial-mesenchymal transition and promotes aggressiveness in bladder cancer. PMID: 24504366
    14. It significantly inhibited activity of eIF5A2. PMID: 24262005
    15. None of the latter died within 5 years in EIF5A2-negative staining group. PMID: 24178756
    16. eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient sample PMID: 22927971
    17. EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition. PMID: 21813470
    18. EIF5A2 plays an important role in hepatocellular carcinoma invasion and metastasis by inducing epithelial-mesenchymal transition, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1. PMID: 20112425
    19. role in eukaryotic cell survival similar to that of the ubiquitous eIF5A-1 PMID: 14622290
    20. eIF-5A2 overexpression was significantly associated with the advanced stage of ovarian cancer. PMID: 15205331
    21. Mutations in the human EIF5A2 gene are not common causes of infertility in man PMID: 16169419
    22. In clinical samples, the expression of PTMA was significantly higher in the minor effect group than in the major effect group (P = 0.004), but there were no significant differences in EIF5a2 expression between the two groups. PMID: 17876542
    23. These findings suggest that overexpression of EIF-5A2 in colorectal carcinomas may be important in the acquisition of a metastatic phenotype and plays an important role in colorectal carcinoma development and progression. PMID: 17949776
    24. Increased expression of EIF-5A2 in ovarian carcinoma may represent an acquired malignant phenotypic feature of tumor cells. Overexpression of EIF-5A2 is an independent molecular marker for shortened survival time of patients with ovarian carcinoma. PMID: 19054548
    25. Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy. PMID: 19155439
    26. protein expression of eIF-5A2 might be regulated not only by gene amplification, but also by other molecular mechanisms PMID: 19298601
    27. Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Human EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII. PMID: 11161802

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex.
  • 蛋白家族：
    EIF-5A family
  • 组织特异性：
    Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.
  • 数据库链接：

    HGNC: 3301

    OMIM: 605782

    KEGG: hsa:56648

    STRING: 9606.ENSP00000295822

    UniGene: Hs.164144