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  4. Recombinant Human Eukaryotic translation initiation factor 5A-2 (EIF5A2)

Recombinant Human Eukaryotic translation initiation factor 5A-2 (EIF5A2)

  • 中文名称：
    人EIF5A2重组蛋白
  • 货号：
    CSB-YP872418HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人EIF5A2重组蛋白
  • 货号：
    CSB-EP872418HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人EIF5A2重组蛋白
  • 货号：
    CSB-EP872418HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人EIF5A2重组蛋白
  • 货号：
    CSB-BP872418HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人EIF5A2重组蛋白
  • 货号：
    CSB-MP872418HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EIF5A2
  • Uniprot No.：
  • 别名：
    9630038B20; eIF 5A 2; eIF 5A2; eIF-4D; eIF-5A-2; eIF-5A2; EIF5A 2; EIF5A2; eIF5AII; Eukaryotic initiation factor 5A isoform 2; Eukaryotic translation initiation factor 5A-2; Eukaryotic translation initiation factor 5A2; IF5A2_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-153
  • 氨基酸序列
    ADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS LLTETGEVRE DLKLPEGELG KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK PCK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.
  • 基因功能参考文献：
    1. EIF5A2 as a direct and functional target of miR-203. PMID: 27376958
    2. The model had 92% sensitivity and 92% specificity. We obtained similar results in the independent validation cohort. AIB1 and EIF5A2 show promise for the noninvasive detection of bladder cancer. The model based on AIB1, EIF5A2, and NMP22 outperformed each of the three individual biomarkers for detecting Bladder cancer. PMID: 27203388
    3. Data suggest that inhibition of eIF5A2 alters progression of the EMT to decrease the invasion and metastasis of HCC cells via ROS-related pathways. PMID: 27028999
    4. EIF5A2 overexpression may contribute to cancer progression and poor prognosis. Therefore, EIF5A2 could be a novel potential prognostic marker for Federation of Gynecology and Obstetrics (FIGO) stage I-II cervical cancer. PMID: 26799253
    5. High EIF5A2 expression is associated with hepatocellular carcinoma. PMID: 27879277
    6. MiR-30b suppresses tumor migration and invasion by targeting EIF5A2 expression in gastric cancer cells. PMID: 26309359
    7. eIF-5A2 plays an important role in doxorubicin chemoresistance in breast cancer cells. PMID: 24638963
    8. Data indicate that regulation of sonic hedgehog (SHh)-GLI family zinc finger 1 (Gli1) signals to migration of pancreatic cancer AsPC-1 Cells through mediating eukaryotic translation initiation factor 5A (EIF5A2) gene expression. PMID: 26465952
    9. Data suggest that eukaryotic translation initiation factor 5A2 (EIF5A2) inhibitors might be considered as combination therapy to enhance chemosensitivity in patients with esophageal squamous cell carcinoma (ESCC). PMID: 26317793
    10. Our findings indicate that EIF5A2 upregulation plays an important oncogenic role in gastric cancer. EIF5A2 may represent a new predictor for poor survival and is a potential therapeutic target for gastric cancer. PMID: 25793713
    11. Increased expression of eIF5A2 increases metastasis and angiogenesis in esophageal squamous cell carcinoma via the HIF1alpha-mediated signaling pathway. PMID: 24561231
    12. focus on updating current knowledge of the EIF5A2 gene in human cancers PMID: 24250246
    13. EIF5A2 elevated TGF-beta1 expression through STAT3 to induce epithelial-mesenchymal transition and promotes aggressiveness in bladder cancer. PMID: 24504366
    14. It significantly inhibited activity of eIF5A2. PMID: 24262005
    15. None of the latter died within 5 years in EIF5A2-negative staining group. PMID: 24178756
    16. eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient sample PMID: 22927971
    17. EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition. PMID: 21813470
    18. EIF5A2 plays an important role in hepatocellular carcinoma invasion and metastasis by inducing epithelial-mesenchymal transition, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1. PMID: 20112425
    19. role in eukaryotic cell survival similar to that of the ubiquitous eIF5A-1 PMID: 14622290
    20. eIF-5A2 overexpression was significantly associated with the advanced stage of ovarian cancer. PMID: 15205331
    21. Mutations in the human EIF5A2 gene are not common causes of infertility in man PMID: 16169419
    22. In clinical samples, the expression of PTMA was significantly higher in the minor effect group than in the major effect group (P = 0.004), but there were no significant differences in EIF5a2 expression between the two groups. PMID: 17876542
    23. These findings suggest that overexpression of EIF-5A2 in colorectal carcinomas may be important in the acquisition of a metastatic phenotype and plays an important role in colorectal carcinoma development and progression. PMID: 17949776
    24. Increased expression of EIF-5A2 in ovarian carcinoma may represent an acquired malignant phenotypic feature of tumor cells. Overexpression of EIF-5A2 is an independent molecular marker for shortened survival time of patients with ovarian carcinoma. PMID: 19054548
    25. Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy. PMID: 19155439
    26. protein expression of eIF-5A2 might be regulated not only by gene amplification, but also by other molecular mechanisms PMID: 19298601
    27. Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Human EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII. PMID: 11161802

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex.
  • 蛋白家族：
    EIF-5A family
  • 组织特异性：
    Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.
  • 数据库链接：

    HGNC: 3301

    OMIM: 605782

    KEGG: hsa:56648

    STRING: 9606.ENSP00000295822

    UniGene: Hs.164144