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  4. EVL Antibody

EVL Antibody

  • 中文名称：
    EVL兔多克隆抗体
  • 货号：
    CSB-PA007869GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UI08
  • 基因名：
    EVL
  • 别名：
    EVL antibody; RNB6Ena/VASP-like protein antibody; Ena/vasodilator-stimulated phosphoprotein-like antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EVL
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
  • 基因功能参考文献：
    1. EVL/miR-342 methylation was preferentially detected in IgD multiple myeloma PMID: 29242101
    2. Identify CRMP-1 as a novel regulator of actin filament elongation and reveal a surprisingly important role for CRMP-1, EVL, and actin polymerization in maintaining the structural integrity of epithelial sheets. PMID: 28630144
    3. ENA/VASP-family proteins are functionally redundant in homologous recombination, and MENA, VASP and EVL may be involved in the DSB repair pathway in humans PMID: 21398369
    4. EVL, with either E. coli topoisomerase I or human topoisomerase IIIalpha, catalyzed ssDNA catenation. PMID: 20639531
    5. Ena/VASP proteins regulate actin polymerization at actin filament barbed ends in vitro in the presence and absence of barbed end capping proteins. PMID: 15939738
    6. the interaction of the alphaII-spectrin SH3 domain with EVL PMID: 16336193
    7. Data suggest that ena/VASP binding to F-actin allows for gephyrin recruitment to the leading edge of uncapped actin filaments. PMID: 16376568
    8. EVL is required for endothelial barrier function in vivo. PMID: 17998398
    9. A microRNA encoded in an intron of the gene EVL, is commonly suppressed in human colorectal cancer. PMID: 18264139
    10. EVL may be implicated in invasion and/or metastasis of human breast cancer. PMID: 18357390
    11. EVL protein is a novel recombination factor that may be required for repairing specific DNA lesions, and that may cause tumor malignancy by its inappropriate expression. PMID: 19329439
    12. EVH2 domain, which is highly conserved among the ENA/VASP family proteins, may be responsible for the recombination function of EVL. PMID: 19725871

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell projection, lamellipodium.
  • 蛋白家族：
    Ena/VASP family
  • 数据库链接：

    HGNC: 20234

    KEGG: hsa:51466

    STRING: 9606.ENSP00000376652

    UniGene: Hs.125867