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  4. EXOC2 Antibody

EXOC2 Antibody

  • 货号：
    CSB-PA007878GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96KP1
  • 基因名：
  • 别名：
    EXOC2 antibody; EXOC2_HUMAN antibody; Exocyst complex component 2 antibody; Exocyst complex component Sec5 antibody; FLJ11026 antibody; SEC5 antibody; SEC5 like 1 antibody; SEC5L1 antibody; Sec5p antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SEC5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
  • 基因功能参考文献：
    1. data suggest that the induction of SGK1 through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites. PMID: 26359301
    2. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. PMID: 23844030
    3. We identified interactions between RalA and its effectors sec5 and exo84 in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells. PMID: 22761837
    4. Data show that Mc1R, HERC2, IRF4, TYR and EXOC2 are ranked highest in hair color prediction analysis. PMID: 21197618
    5. shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells. PMID: 20145037
    6. SEC5 has been identified as a binding partner of deafness locus putative guanine nucleotide exchange factor. PMID: 12459492
    7. evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 PMID: 14525976
    8. These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. PMID: 17018283
    9. Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin. PMID: 18697830
    10. Functional study of the Drosophila homolog. PMID: 12575951

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  • 亚细胞定位：
    Midbody, Midbody ring.
  • 蛋白家族：
    SEC5 family
  • 组织特异性：
    Widely expressed with highest levels in brain and placenta.
  • 数据库链接：

    HGNC: 24968

    OMIM: 615329

    KEGG: hsa:55770

    STRING: 9606.ENSP00000230449

    UniGene: Hs.484412