EXOC2 Antibody
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货号:CSB-PA007878ESR1HU
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规格:¥440
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促销:
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图片:
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) EXOC2 Polyclonal antibody
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Uniprot No.:Q96KP1
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基因名:
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别名:EXOC2 antibody; EXOC2_HUMAN antibody; Exocyst complex component 2 antibody; Exocyst complex component Sec5 antibody; FLJ11026 antibody; SEC5 antibody; SEC5 like 1 antibody; SEC5L1 antibody; Sec5p antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Exocyst complex component 2 protein (1-220AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式:Liquid
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应用范围:ELISA, IHC
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推荐稀释比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
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基因功能参考文献:
- data suggest that the induction of SGK1 through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites. PMID: 26359301
- Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. PMID: 23844030
- We identified interactions between RalA and its effectors sec5 and exo84 in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells. PMID: 22761837
- Data show that Mc1R, HERC2, IRF4, TYR and EXOC2 are ranked highest in hair color prediction analysis. PMID: 21197618
- shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells. PMID: 20145037
- SEC5 has been identified as a binding partner of deafness locus putative guanine nucleotide exchange factor. PMID: 12459492
- evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 PMID: 14525976
- These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. PMID: 17018283
- Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin. PMID: 18697830
- Functional study of the Drosophila homolog. PMID: 12575951
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亚细胞定位:Midbody, Midbody ring.
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蛋白家族:SEC5 family
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组织特异性:Widely expressed with highest levels in brain and placenta.
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数据库链接:
HGNC: 24968
OMIM: 615329
KEGG: hsa:55770
STRING: 9606.ENSP00000230449
UniGene: Hs.484412
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