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FBXO18 Antibody

  • 中文名称：
    FBXO18兔多克隆抗体
  • 货号：
    CSB-PA008486GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8NFZ0
  • 基因名：
    FBXO18
  • 别名：
    F box DNA helicase 1 antibody; F box only protein 18 antibody; F box only protein helicase 18 antibody; F box protein, helicase, 18 antibody; F-box DNA helicase 1 antibody; F-box only protein 18 antibody; FBH1 antibody; Fbx18 antibody; FBX18_HUMAN antibody; Fbxo18 antibody; FLJ14590 antibody; MGC131916 antibody; MGC141935 antibody; MGC141937 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human FBXO18
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location.
  • 基因功能参考文献：
    1. Report a requirement for PARP2 in stabilizing replication forks that encounter base excision repair (BER) intermediates through Fbh1-dependent regulation of Rad51. Whereas PARP2 is dispensable for tolerance of cells to single stranded breaks or homologous recombination dysfunction, it is redundant with PARP1 in BER. PMID: 29467415
    2. study does not provide evidence for the contribution of rare non-synonymous FBXO18 variations to the genetic etiol - ogy of schizophrenia in the Japanese population. PMID: 28317220
    3. FBH1 acts as a negative regulator of RAD51 function in human cells PMID: 25585578
    4. FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination. PMID: 24108124
    5. FBH1 inactivation appears to contribute to oncogenic transformation by allowing survival of cells undergoing replicative stress due to external factors such as UV irradiation. PMID: 23466708
    6. The study reports a mechanism that controls the degradation of FBH1 after DNA damage. PMID: 23677613
    7. Ubiquitylation affects FBH1 interaction with the RAD51 nucleoprotein filament, but not its translocase and helicase activities. PMID: 23393192
    8. FBH1 helicase activity is required for the efficient induction of DSBs and apoptosis specifically in response to DNA replication stress. PMID: 23319600
    9. hFBH1 exhibited DNA-dependent ATPase and DNA unwinding activities that displace duplex DNA in the 3' to 5' direction. PMID: 11956208
    10. These findings suggest that the hFBH1 helicase is a functional human orthologue of budding yeast Srs2 that also possesses self-regulation properties necessary to execute its recombination functions. PMID: 17724085
    11. Data show that the human Fbh1 (hFbh1) helicase accumulates at sites of DNA damage or replication stress in a manner dependent fully on its helicase activity and partially on its conserved F box. PMID: 19736316

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  • 相关疾病：
    Defects in FBXO18 are frequently observed in melanomas, resulting in increased survival in response to replicative stress. Its inactivation may play a role in oncogenic transformation.
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Helicase family, UvrD subfamily
  • 数据库链接：

    HGNC: 13620

    OMIM: 607222

    KEGG: hsa:84893

    STRING: 9606.ENSP00000369335

    UniGene: Hs.498543