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GABRD Antibody

  • 中文名称：
    GABRD兔多克隆抗体
  • 货号：
    CSB-PA008564
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O14764
  • 基因名：
    GABRD
  • 别名：
    GABA(A) receptor subunit delta antibody; Gabrd antibody; Gamma aminobutyric acid GABA A receptor delta antibody; Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor antibody; Gamma-aminobutyric acid receptor subunit delta antibody; GBRD_HUMAN antibody; MGC45284 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GABAA Rδ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能参考文献：
    1. This study found that increased methylation of the promoter of the delta subunit GABAA receptor was associated with reduced mRNA and protein levels in the cerebellum of alcohol use disorder subjects. PMID: 29020412
    2. Genome-wide association studies identify GABRD mutation releated to juvenile myoclonic epilepsy PMID: 23756480
    3. In recombinant human cDNA experiments in HEK293 cells, delta subunit coexpression leads to receptors activated by nanomolar THIP concentrations. PMID: 21795619
    4. These findings point to the GABRD gene as a susceptibility gene for COMD. PMID: 20561060
  • 相关疾病：
    Generalized epilepsy with febrile seizures plus 5 (GEFS+5); Epilepsy, idiopathic generalized 10 (EIG10); Juvenile myoclonic epilepsy 7 (EJM7)
  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRD sub-subfamily
  • 数据库链接：

    HGNC: 4084

    OMIM: 137163

    KEGG: hsa:2563

    STRING: 9606.ENSP00000367848

    UniGene: Hs.113882