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GAR1 Antibody

  • 中文名称：
    GAR1兔多克隆抗体
  • 货号：
    CSB-PA878917LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA878917LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GAR1 Polyclonal antibody
  • Uniprot No.：
    Q9NY12
  • 基因名：
    GAR1
  • 别名：
    Gar1 antibody; GAR1_HUMAN antibody; H/ACA ribonucleoprotein complex subunit 1 antibody; nucleolar protein family A member 1 (H/ACA small nucleolar RNPs) antibody; Nucleolar protein family A member 1 antibody; snoRNP protein GAR1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human H/ACA ribonucleoprotein complex subunit 1 protein (1-217AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GAR1 Antibody (CSB-PA878917LA01HU)，的标记方式是Non-conjugated。对于GAR1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA878917LB01HU GAR1 Antibody, HRP conjugated ELISA
    FITC CSB-PA878917LC01HU GAR1 Antibody, FITC conjugated
    Biotin CSB-PA878917LD01HU GAR1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
  • 基因功能参考文献：
    1. The deregulated expression and function of H/ACA snoRNPs may underlie specific pathological features of human disease. PMID: 23707062
    2. The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification. PMID: 19917616
    3. heterozygous point mutations in NOLA1 gene are not responsible for aplastic anemia in our patients at least acting via telomere PMID: 18989882
  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
  • 蛋白家族：
    GAR1 family
  • 数据库链接：

    HGNC: 14264

    OMIM: 606468

    KEGG: hsa:54433

    STRING: 9606.ENSP00000226796

    UniGene: Hs.69851