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GBP5 Antibody

  • 货号：
    CSB-PA006865
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q96PP8
  • 基因名：
  • 别名：
    GBP 5 antibody; GBP TA antigen antibody; GBP-5 antibody; GBP-TA antigen antibody; GBP5 antibody; GBP5_HUMAN antibody; GTP binding protein 5 antibody; GTP-binding protein 5 antibody; Guanine nucleotide binding protein 5 antibody; Guanine nucleotide-binding protein 5 antibody; Guanylate binding protein 5 antibody; Guanylate-binding protein 5 antibody; UNQ2427/PRO4987 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GBP5.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP.
  • 基因功能参考文献：
    1. GBP5 and KLF2 may be useful as a diagnostic tool for active tuberculosis, also the two-gene set may serve as surrogate biomarkers for monitoring tuberculosis therapy. PMID: 28941629
    2. these results reveal that GBP5 inhibited influenza virus replication through the activation of IFN signaling and proinflammatory factors PMID: 28376501
    3. Previously reported tetrameric and dimeric species of hGBP-1 and hGBP-5 were unmasked as dimers and monomers, respectively, with their shapes depending on both the bound nucleotide and the ionic strength of the solution. PMID: 28580591
    4. Antiviral activity requires Golgi localization of GBP5, but not its GTPase activity. PMID: 26996307
    5. GZMA, GBP5 and CD64 genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases. PMID: 26025597
    6. The in vivo localization of GBP-5 at the Golgi apparatus is regulated by isoprenylation and dimerization. PMID: 21151871
    7. analysis of guanylate binding protein 5 and a tumor-specific truncated splice variant PMID: 20180847
    8. Eight of nine melanoma cell lines expressed GBP-5a/b and four of nine additionally low levels of GBP-5ta. PMID: 15175044
    9. 3 genes were upregulated in patients with chronic EBV infection: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5; they may be associated with the inflammatory reaction or with cell proliferation. PMID: 18260761
    10. GBP5 is constitutively localized in the Golgi apparatus of endothelial cells. PMID: 17266443

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus membrane; Lipid-anchor.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
  • 组织特异性：
    Expressed in peripheral blood monocytes (at protein level).
  • 数据库链接：

    HGNC: 19895

    OMIM: 611467

    KEGG: hsa:115362

    STRING: 9606.ENSP00000340396

    UniGene: Hs.513726