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  4. Recombinant Human Guanylate-binding protein 5 (GBP5)

Recombinant Human Guanylate-binding protein 5 (GBP5)

  • 中文名称：
    人GBP5重组蛋白
  • 货号：
    CSB-YP847203HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GBP5重组蛋白
  • 货号：
    CSB-EP847203HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GBP5重组蛋白
  • 货号：
    CSB-EP847203HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GBP5重组蛋白
  • 货号：
    CSB-BP847203HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GBP5重组蛋白
  • 货号：
    CSB-MP847203HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    GBP 5; GBP TA antigen; GBP-5; GBP-TA antigen; GBP5; GBP5_HUMAN; GTP binding protein 5; GTP-binding protein 5; Guanine nucleotide binding protein 5; Guanine nucleotide-binding protein 5; Guanylate binding protein 5; Guanylate-binding protein 5; UNQ2427/PRO4987
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-583
  • 氨基酸序列
    MALEIHMSDP MCLIENFNEQ LKVNQEALEI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG KNKGFSVAST VQSHTKGIWI WCVPHPNWPN HTLVLLDTEG LGDVEKADNK NDIQIFALAL LLSSTFVYNT VNKIDQGAID LLHNVTELTD LLKARNSPDL DRVEDPADSA SFFPDLVWTL RDFCLGLEID GQLVTPDEYL ENSLRPKQGS DQRVQNFNLP RLCIQKFFPK KKCFIFDLPA HQKKLAQLET LPDDELEPEF VQQVTEFCSY IFSHSMTKTL PGGIMVNGSR LKNLVLTYVN AISSGDLPCI ENAVLALAQR ENSAAVQKAI AHYDQQMGQK VQLPMETLQE LLDLHRTSER EAIEVFMKNS FKDVDQSFQK ELETLLDAKQ NDICKRNLEA SSDYCSALLK DIFGPLEEAV KQGIYSKPGG HNLFIQKTEE LKAKYYREPR KGIQAEEVLQ KYLKSKESVS HAILQTDQAL TETEKKKKEA QVKAEAEKAE AQRLAAIQRQ NEQMMQERER LHQEQVRQME IAKQNWLAEQ QKMQEQQMQE QAAQLSTTFQ AQNRSLLSEL QHAQRTVNND DPC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP.
  • 基因功能参考文献：
    1. GBP5 and KLF2 may be useful as a diagnostic tool for active tuberculosis, also the two-gene set may serve as surrogate biomarkers for monitoring tuberculosis therapy. PMID: 28941629
    2. these results reveal that GBP5 inhibited influenza virus replication through the activation of IFN signaling and proinflammatory factors PMID: 28376501
    3. Previously reported tetrameric and dimeric species of hGBP-1 and hGBP-5 were unmasked as dimers and monomers, respectively, with their shapes depending on both the bound nucleotide and the ionic strength of the solution. PMID: 28580591
    4. Antiviral activity requires Golgi localization of GBP5, but not its GTPase activity. PMID: 26996307
    5. GZMA, GBP5 and CD64 genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases. PMID: 26025597
    6. The in vivo localization of GBP-5 at the Golgi apparatus is regulated by isoprenylation and dimerization. PMID: 21151871
    7. analysis of guanylate binding protein 5 and a tumor-specific truncated splice variant PMID: 20180847
    8. Eight of nine melanoma cell lines expressed GBP-5a/b and four of nine additionally low levels of GBP-5ta. PMID: 15175044
    9. 3 genes were upregulated in patients with chronic EBV infection: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5; they may be associated with the inflammatory reaction or with cell proliferation. PMID: 18260761
    10. GBP5 is constitutively localized in the Golgi apparatus of endothelial cells. PMID: 17266443

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus membrane; Lipid-anchor.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
  • 组织特异性：
    Expressed in peripheral blood monocytes (at protein level).
  • 数据库链接：

    HGNC: 19895

    OMIM: 611467

    KEGG: hsa:115362

    STRING: 9606.ENSP00000340396

    UniGene: Hs.513726