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  4. GFRA4 Antibody

GFRA4 Antibody

  • 货号：
    CSB-PA050010
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9GZZ7
  • 基因名：
    GFRA4
  • 别名：
    GDNF family receptor alpha 4 antibody; GDNF family receptor alpha-4 antibody; GDNF receptor alpha-4 antibody; GDNFR-alpha-4 antibody; GFR alpha 4 antibody; GFR receptor alpha 4 antibody; GFR-alpha-4 antibody; GFRA4 antibody; GFRA4_HUMAN antibody; Glial cell line derived neurotrophic factor family receptor alpha 4 antibody; Neurotrophic factor receptor splice variant A (Gfra4 gene) antibody; OTTHUMP00000030106 antibody; OTTHUMP00000030107 antibody; Persephin receptor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GFRα-4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
  • 基因功能参考文献：
    1. Results support that aberrant CpG hypermethylation at least partly accounts for GFRA4 silencing in HSCR, which impairs its protective role in enteric nervous system. PMID: 29634418
    2. High GFRA4 expression is associated with Hirschsprung's Disease. PMID: 29090971
    3. GDNF/GFRalpha1 is crucial for efficient signal transduction to recruit Ret protein into lipid rafts. PMID: 15225646
  • 亚细胞定位：
    [Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.
  • 蛋白家族：
    GDNFR family
  • 组织特异性：
    Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
  • 数据库链接：

    HGNC: 13821

    KEGG: hsa:64096

    STRING: 9606.ENSP00000313423

    UniGene: Hs.302025