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  4. Recombinant Human GDNF family receptor alpha-4 (GFRA4)

Recombinant Human GDNF family receptor alpha-4 (GFRA4)

Unavailable
  • 中文名称：
    人GFRA4重组蛋白
  • 货号：
    CSB-YP863936HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GFRA4重组蛋白
  • 货号：
    CSB-EP863936HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GFRA4重组蛋白
  • 货号：
    CSB-EP863936HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GFRA4重组蛋白
  • 货号：
    CSB-BP863936HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GFRA4重组蛋白
  • 货号：
    CSB-MP863936HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GFRA4
  • Uniprot No.：
  • 别名：
    GDNF family receptor alpha 4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107; Persephin receptor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-278
  • 氨基酸序列
    VGGNRCVDAA EACTADARCQ RLRSEYVAQC LGRAAQGGCP RARCRRALRR FFARGPPALT HALLFCPCAG PACAERRRQT FVPSCAFSGP GPAPPSCLEP LNFCERSRVC RCARAAAGPW RGWGRGLSPA HRPPAAQASP PGLSGLVHPS AQRPRRLPAG PGRPLPARLR GPRGVPAGTA VTPNYVDNVS ARVAPWCDCG ASGNRREDCE AFRGLFTRNR CLDGAIQAFA SGWPPVLLDQ LNPQGDPEHS LLQVSSTG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
  • 基因功能参考文献：
    1. Results support that aberrant CpG hypermethylation at least partly accounts for GFRA4 silencing in HSCR, which impairs its protective role in enteric nervous system. PMID: 29634418
    2. High GFRA4 expression is associated with Hirschsprung's Disease. PMID: 29090971
    3. GDNF/GFRalpha1 is crucial for efficient signal transduction to recruit Ret protein into lipid rafts. PMID: 15225646
  • 亚细胞定位：
    [Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.
  • 蛋白家族：
    GDNFR family
  • 组织特异性：
    Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
  • 数据库链接：

    HGNC: 13821

    KEGG: hsa:64096

    STRING: 9606.ENSP00000313423

    UniGene: Hs.302025