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HEMGN Antibody

  • 货号：
    CSB-PA010284GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BXL5
  • 基因名：
    HEMGN
  • 别名：
    CT155 antibody; EDAG antibody; EDAG-1 antibody; Erythroid differentiation-associated gene protein antibody; Hemgn antibody; HEMGN_HUMAN antibody; Hemogen antibody; Hemopoietic gene protein antibody; NDR antibody; Negative differentiation regulator protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human HEMGN
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
  • 基因功能参考文献：
    1. Using ex vivo culture and HSC transplantation models, study finds that EDAG enhances proliferative potential of human cord blood CD34+ cells, increases survival, prevents cell apoptosis and promotes their repopulating capacity. EDAG overexpression induces rapid entry of CD34+ cells into the cell cycle. Gene expression profile analysis shows that EDAG knockdown leads to down-regulation of positive cell cycle regulators. PMID: 29324880
    2. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8 PMID: 27579896
    3. EDAG-1 regulates the proliferation and apoptosis of thyroid carcinoma via the PI3K/Akt signaling pathway. PMID: 27261581
    4. EDAG forms complex with GATA1 and p300 and increases GATA1 acetylation and transcriptional activity by facilitating the interaction between GATA1 and p300 PMID: 24740910
    5. EDAG enhances the protein stability of NPM1 via binding to NPM1, which plays a critical role in the anti-apoptosis of leukaemia cells. PMID: 22712502
    6. EDAG functions as a positive regulator of erythroid/megakaryocytic differentiation in 32D cells associated with the induction of GATA-1 and its target genes PMID: 20564185
    7. results suggest a novel function of nuclear negative differentiation regulator (NDR) protein in regulating hematopoietic cell development [NDR] PMID: 14730214
    8. These results suggest that EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of NF-kappa B. PMID: 15332117
    9. Hemgn promoter contains critical regulatory elements for its transcription in hematopoietic tissues and Hemgn is a direct target of GATA1 in leukemia cells PMID: 16437149
    10. The stable transfected cells were identified with RT-PCR and the effect of EDAG/siRNA on the growth of the human erythroleukemia cell line HEL was analyzed. PMID: 17671716
    11. The inhibition of the EDAG gene by PMA is mediated through down-regulation of transcription factor GATA-1 . PMID: 18599389

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various le
  • 数据库链接：

    HGNC: 17509

    OMIM: 610715

    KEGG: hsa:55363

    STRING: 9606.ENSP00000259456

    UniGene: Hs.176626