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  4. HES6 Antibody

HES6 Antibody

  • 货号：
    CSB-PA002904
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using HES-6 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96HZ4
  • 基因名：
    HES6
  • 别名：
    HES6 antibody; BHLHB41 antibody; Transcription cofactor HES-6 antibody; C-HAIRY1 antibody; Class B basic helix-loop-helix protein 41 antibody; bHLHb41 antibody; Hairy and enhancer of split 6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human HES-6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
  • 基因功能参考文献：
    1. High HES6 expression is associated with metastasis in colorectal cancer. PMID: 30015909
    2. prostate cancer-specific up-regulation of NOTCH3 and HES6, is reported. PMID: 25864518
    3. HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer. PMID: 25006183
    4. HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1. PMID: 24737870
    5. HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility. PMID: 22982728
    6. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. PMID: 21785461
    7. Data suggest that Hes-6 is a potential oncogene overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells. PMID: 19891787
    8. Differentially expressed in metastatic colon carcinoma PMID: 12957362
    9. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity. PMID: 12972610
    10. Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation. PMID: 15896295
    11. Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin expression PMID: 17300753
    12. Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. PMID: 17301032
    13. ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter PMID: 17826772
    14. the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways. PMID: 18160400
    15. These four variants were tested for association with mood disorder diagnosis or antidepressant response in a family study of depression, but no significant associations were observed. PMID: 19481584

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 18254

    OMIM: 610331

    KEGG: hsa:55502

    STRING: 9606.ENSP00000272937

    UniGene: Hs.42949