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  4. Recombinant Human Transcription cofactor HES-6 (HES6)

Recombinant Human Transcription cofactor HES-6 (HES6)

  • 中文名称：
    人HES6重组蛋白
  • 货号：
    CSB-YP839339HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HES6重组蛋白
  • 货号：
    CSB-EP839339HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HES6重组蛋白
  • 货号：
    CSB-EP839339HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HES6重组蛋白
  • 货号：
    CSB-BP839339HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HES6重组蛋白
  • 货号：
    CSB-MP839339HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HES6
  • Uniprot No.：
  • 别名：
    HES6; BHLHB41; Transcription cofactor HES-6; C-HAIRY1; Class B basic helix-loop-helix protein 41; bHLHb41; Hairy and enhancer of split 6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-224
  • 氨基酸序列
    MAPPAAPGRD RVGREDEDGW ETRGDRKARK PLVEKKRRAR INESLQELRL LLAGAEVQAK LENAEVLELT VRRVQGVLRG RAREREQLQA EASERFAAGY IQCMHEVHTF VSTCQAIDAT VAAELLNHLL ESMPLREGSS FQDLLGDALA GPPRAPGRSG WPAGGAPGSP IPSPPGPGDD LCSDLEEAPE AELSQAPAEG PDLVPAALGS LTTAQIARSV WRPW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
  • 基因功能参考文献：
    1. High HES6 expression is associated with metastasis in colorectal cancer. PMID: 30015909
    2. prostate cancer-specific up-regulation of NOTCH3 and HES6, is reported. PMID: 25864518
    3. HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer. PMID: 25006183
    4. HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1. PMID: 24737870
    5. HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility. PMID: 22982728
    6. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. PMID: 21785461
    7. Data suggest that Hes-6 is a potential oncogene overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells. PMID: 19891787
    8. Differentially expressed in metastatic colon carcinoma PMID: 12957362
    9. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity. PMID: 12972610
    10. Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation. PMID: 15896295
    11. Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin expression PMID: 17300753
    12. Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. PMID: 17301032
    13. ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter PMID: 17826772
    14. the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways. PMID: 18160400
    15. These four variants were tested for association with mood disorder diagnosis or antidepressant response in a family study of depression, but no significant associations were observed. PMID: 19481584

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 18254

    OMIM: 610331

    KEGG: hsa:55502

    STRING: 9606.ENSP00000272937

    UniGene: Hs.42949