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HES7 Antibody

  • 货号：
    CSB-PA887160LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA887160LA01HU diluted at 1:400 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HES7 Polyclonal antibody
  • Uniprot No.：
    Q9BYE0
  • 基因名：
    HES7
  • 别名：
    bHLH factor Hes7 antibody; bHLHb37 antibody; Class B basic helix loop helix protein 37 antibody; Class B basic helix-loop-helix protein 37 antibody; Hairy and enhancer of split 7 antibody; hes family bHLH transcription factor 7 antibody; Hes7 antibody; HES7_HUMAN antibody; hHes7 antibody; SCDO4 antibody; Transcription factor HES 7 antibody; Transcription factor HES-7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transcription factor HES-7 protein (127-192AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HES7 Antibody (CSB-PA887160LA01HU)，的标记方式是Non-conjugated。对于HES7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA887160LB01HU HES7 Antibody, HRP conjugated ELISA
    FITC CSB-PA887160LC01HU HES7 Antibody, FITC conjugated
    Biotin CSB-PA887160LD01HU HES7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.
  • 基因功能参考文献：
    1. mutation of HES7 is uniquely associated with defects in vertebral, heart and neural tube formation, and this observation will help provide a discriminatory diagnostic guide in patients with SCD, as well as inform molecular genetic testing. PMID: 23897666
    2. MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population. PMID: 22744456
    3. Two new missense mutations in HES7 in a family with spondylocostal dysostosis. PMID: 20087400
    4. R25W missense mutation of HES7 is causative of Spondylocostal dysostosis. PMID: 18775957
  • 相关疾病：
    Spondylocostal dysostosis 4, autosomal recessive (SCDO4)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 15977

    OMIM: 608059

    KEGG: hsa:84667

    STRING: 9606.ENSP00000446205

    UniGene: Hs.434828