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HGFAC Antibody

  • 货号：
    CSB-PA004694
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 Jurkat cells using HGFA Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q04756
  • 基因名：
    HGFAC
  • 别名：
    HGFAC antibody; Hepatocyte growth factor activator antibody; HGF activator antibody; HGFA antibody; EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human HGFA.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
  • 基因功能参考文献：
    1. the HGF-activator has a role in multiple myeloma cells' catalysis of hepatocyte growth factor (HGF) activation PMID: 15172968
    2. HGF/MET signaling and aberrant HGF-activator expression is associated with diffuse large B-cell lymphoma PMID: 16189274
    3. KLK4 and KLK5 activate pro-HGFA. PMID: 18221492
    4. Results suggest that hepatocyte growth factor activator is a major serum activator of pro-macrophage-stimulating protein. PMID: 19456860
    5. HAI-1 (serine peptidase inhibitor, Kunitz type 1) specifically traps active form of HGF activator on cellular surface and regulates HGF activation in pericellular microenvironment. PMID: 11013244

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  • 亚细胞定位：
    Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
  • 蛋白家族：
    Peptidase S1 family
  • 组织特异性：
    Liver.
  • 数据库链接：

    HGNC: 4894

    OMIM: 604552

    KEGG: hsa:3083

    STRING: 9606.ENSP00000372224

    UniGene: Hs.104