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HIST2H3A Antibody

  • 中文名称：
    HIST2H3A兔多克隆抗体
  • 货号：
    CSB-PA744479HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: HIST2H3A antibody at 14 μg/ml
      Lane 1: Mouse liver tissue
      Lane 2: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 15 kDa
      Observed band size: 15 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA744479HA01HU at dilution of 1: 100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA744479HA01HU at dilution of 1: 100
    • Immunofluorescent analysis of Hela cells using CSB-PA744479HA01HU at dilution of 1: 100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HIST2H3A; Polyclonal antibody
  • Uniprot No.：
    Q71DI3
  • 基因名：
    HIST2H3A;
  • 别名：
    HIST2H3A; antibody; HIST2H3C antibody; H3F2 antibody; H3FM; antibody; HIST2H3D antibody; Histone H3.2 antibody; Histone H3/m antibody; Histone H3/o antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Histone H3.2 protein (108-136AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HIST2H3A Antibody (CSB-PA744479HA01HU)，的标记方式是Non-conjugated。对于HIST2H3A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA744479HB01HU HIST2H3A Antibody, HRP conjugated ELISA
    FITC CSB-PA744479HC01HU HIST2H3A Antibody, FITC conjugated
    Biotin CSB-PA744479HD01HU HIST2H3A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • 基因功能参考文献：
    1. Finally, mutations of H3G34 or H3P38 alleviate the inhibitory effects of H3K36M on H3K36 methylation, demonstrating that the stable interaction of H3K36M with SETD2 is critical for its inhibitory effects. PMID: 28256625
    2. Studies presented here confirm that the adenovirus 2 large E1A protein activation domain interacts with p300, as reported previously (P. Pelka, J. N. G. Ablack, J. Torchia, A. S. Turnell, R. J. A. Grand, J. S. Mymryk, Nucleic Acids Res 37:1095-1106, 2009), and that the resulting acetylation of H3K18/27 affects varied steps in transcription at different viral promoters. PMID: 29976669
    3. This study presented the H3 K27M mutations in posterior fossa ependymomas. PMID: 27539613
    4. Findings point to epigenetic mark H3K27me3 as an important event in prostate carcinogenesis and progression. PMID: 28403887
    5. Study identified phosphorylation of histone H3 at serine 10 (H3S10ph) as a histone post-translational modifications with most consistent and significant difference between gastric cancer (GC) tumor and negative resection margin. H3S10 phosphorylation in GC is mediated by MSK1 through the p38- MAPK pathway. PMID: 27588146
    6. Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3. PMID: 26272979
    7. Results identified histone H3K27me3 as elevated in aggressive melanoma cells relative to less aggressive melanoma cells in cell culture and in patient tissues. PMID: 26621846
    8. Study shows proteolytic processing of H2B and H3 in hepatocytes where four different clipping sites were localized in H3 and one in H2B. Also, clipped H3 carry distinct co-existing post-translational modifications but different from those in intact H3. PMID: 26424599
    9. Locally generated fumarate inhibits KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 Lys 36. PMID: 26237645
    10. In vitro clipping assays confirmed the ability of both Neisseria meningitidis proteins, App and MspA, to proteolytically cleave the core histone H3. PMID: 25600171
    11. H3T80ph, protruding from the nucleosome surface, promotes interactions between adjacent nucleosomes to promote chromatin compaction during mitosis in metazoan cells. PMID: 24275038
    12. UHRF1 PHD finger (including the preceding zinc-Cys4 knuckle) acts together with the adjacent double Tudor domain to specifically recognize the H3K9me3 mark. PMID: 22100450
    13. NASP balances the activity of the heat shock proteins Hsc70 and Hsp90 to direct H3-H4 for degradation by chaperone-mediated autophagy PMID: 22195965
    14. purification of a novel JmjC domain-containing protein, JHDM1 (JmjC domain-containing histone demethylase 1), that specifically demethylates histone H3 at lysine 36 PMID: 16362057
    15. BirA ligase biotinylates K4, K9, K18 and K23 in histone H3. PMID: 18452652
    16. Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. PMID: 19041150
    17. phosphorylation of H3T45 (H3T45ph) increases dramatically in apoptotic cells, around the time of DNA nicking PMID: 19363025
    18. The acetylation of lysine(56) residue of Histone H3 is critical for genomic stability and DNA damage response. PMID: 19411844
    19. Acetylation of H3 K56 does not directly affect the compaction of chromatin and has modest effects on chromatin remodeling. However, H3 K56 acetylation increases DNA breathing 7-fold. PMID: 19818718

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Histone H3 family
  • 数据库链接：

    HGNC: 20505

    OMIM: 142780

    KEGG: hsa:126961

    STRING: 9606.ENSP00000385479

    UniGene: Hs.647745