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HMBOX1 Antibody

  • 中文名称：
    HMBOX1兔多克隆抗体
  • 货号：
    CSB-PA010523GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6NT76
  • 基因名：
    HMBOX1
  • 别名：
    HMBOX1 antibody; HOT1 antibody; TAH1 antibody; Homeobox-containing protein 1 antibody; Homeobox telomere-binding protein 1 antibody; Telomere-associated homeobox-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HMBOX1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres.
  • 基因功能参考文献：
    1. Low HMBOX1 expression is associated with liver cancer progression. PMID: 30015890
    2. HMBOX1 played important role in the high-grade serous ovarian cancer through regulation of proliferation and apoptosis. PMID: 29709478
    3. HMBOX1 may be a potential diagnostic marker in glioma. PMID: 28731165
    4. Our data suggest a possible role of HMBOX1 in regulating radiosensitivity in cervical cancer cells. PMID: 28628186
    5. HMBOX1 regulates intracellular free zinc level by interacting with MT2A to inhibit apoptosis and promote autophagy in vascular endothelial cells. PMID: 26456220
    6. a homeobox-containing protein known as HMBOX1 can directly bind telomeric double-stranded DNA and associate with PML nuclear bodies. PMID: 23813958
    7. HOT1 supports telomerase-dependent telomere elongation. PMID: 23685356
    8. our results revealed a novel regulatory mechanism: miR-30c-1(*) promoted NK cell cytotoxicity against hepatoma cells by targeting HMBOX1. PMID: 22320217
    9. HMBOX1 may function as a negative regulator of IFN-gamma in NK cells. PMID: 21839858
    10. HMBOX1 negatively regulates the expression of NKG2D and the activation of the NKG2D/DAP10 signaling pathway in NK cells. PMID: 21706044
    11. higher HMGB1(homeobox containing 1) levels in Tracheal aspirates are associated with the development of bronchopulmonary dysplasia or death in ventilated premature infants. PMID: 20182437
    12. These findings suggest a distinct role of HMBOX1b, and the control of mRNA splicing might be involved in homeobox genes regulation. PMID: 19757162
    13. decreased expression in hepatic carcinoma PMID: 19728927
    14. Hmbox1 is widely expressed in pancreas and the expression of this gene can also be detected in pallium, hippocampus and hypothalamus PMID: 16825764

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome, telomere. Nucleus, Cajal body. Nucleus, PML body.; [Isoform 5]: Nucleus. Cytoplasm.
  • 组织特异性：
    Ubiquitous. Detected in pancreas, brain, spleen, placenta, prostate, thymus, liver, heart, bone marrow, skeletal muscle, stomach, uterus, testis, kidney, ovary, colon, lung, cardiac muscle and thyroid gland.
  • 数据库链接：

    HGNC: 26137

    KEGG: hsa:79618

    STRING: 9606.ENSP00000287701

    UniGene: Hs.563560