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HPD Antibody

  • 货号：
    CSB-PA010698GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P32754
  • 基因名：
    HPD
  • 别名：
    4 HPPD antibody; 4 hydroxyphenylpyruvate dioxygenase antibody; 4 hydroxyphenylpyruvic acid oxidase antibody; 4-hydroxyphenylpyruvate dioxygenase antibody; 4-hydroxyphenylpyruvic acid oxidase antibody; 4HPPD antibody; GLOD3 antibody; glyoxalase domain containing 3 antibody; HPD antibody; HPPD_HUMAN antibody; HPPDase antibody; PPD antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human HPD
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Key enzyme in the degradation of tyrosine.
  • 基因功能参考文献：
    1. The mutagenesis and structural simulation studies demonstrate the critical and unique role of each ligand in the function of HPPD, and which correlates with their respective co-ordination position. PMID: 26936969
    2. 4-hydroxyphenylpyruvate dioxygenase gene mutation is associated with Hawkinsinuria. PMID: 26226126
    3. Glutamine375 has a critical role for 4-HPPD in orientating the tail and ensuring the conformation of the terminal alpha-helix of the enzyme to maintain the integrity of the active site for biocatalysis. PMID: 23950902
    4. The IIe335Met allele is equivalent to a null mutation while the Asn241Ser allele results in a partially active enzyme with an uncoupled turnover causing elevated haykinin in urine. PMID: 17560158
  • 相关疾病：
    Tyrosinemia 3 (TYRSN3); Hawkinsinuria (HAWK)
  • 蛋白家族：
    4HPPD family
  • 数据库链接：

    HGNC: 5147

    OMIM: 140350

    KEGG: hsa:3242

    STRING: 9606.ENSP00000289004

    UniGene: Hs.2899