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HPD Antibody

  • 货号：
    CSB-PA010698LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: HPD antibody at 4.5µg/ml
      Lane 1: Mouse kidney tissue
      Lane 2: Mouse liver tissue
      Lane 3: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 45, 41 kDa
      Observed band size: 45 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010698LA01HU at dilution of 1:20
    • Immunofluorescent analysis of HepG2 cells using CSB-PA010698LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    Inoculating a rabbit with recombinant human 4-hydroxyphenylpyruvate dioxygenase protein (2-393aa), extracting antibodies from the rabbit serum, and then purifying the collected antibodies via protein G affinity chromatography. The resulting antibody is the HPD polyclonal antibody. It contains minimal impurities, and its purity exceeds 95%.

    This HPD polyclonal is capable of recognizing and binding to HPD protein from human and mouse samples. It has been validated in various experimental settings, including ELISA, WB, IHC, and IF, and can be used for the detection of levels, determination of presence and size, and analysis of the distribution of the HPD protein.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HPD Polyclonal antibody
  • Uniprot No.：
    P32754
  • 基因名：
    HPD
  • 别名：
    4 HPPD antibody; 4 hydroxyphenylpyruvate dioxygenase antibody; 4 hydroxyphenylpyruvic acid oxidase antibody; 4-hydroxyphenylpyruvate dioxygenase antibody; 4-hydroxyphenylpyruvic acid oxidase antibody; 4HPPD antibody; GLOD3 antibody; glyoxalase domain containing 3 antibody; HPD antibody; HPPD_HUMAN antibody; HPPDase antibody; PPD antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human 4-hydroxyphenylpyruvate dioxygenase protein (2-393AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HPD Antibody (CSB-PA010698LA01HU)，的标记方式是Non-conjugated。对于HPD Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010698LB01HU HPD Antibody, HRP conjugated ELISA
    FITC CSB-PA010698LC01HU HPD Antibody, FITC conjugated
    Biotin CSB-PA010698LD01HU HPD Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:10-1:100
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Key enzyme in the degradation of tyrosine.
  • 基因功能参考文献：
    1. The mutagenesis and structural simulation studies demonstrate the critical and unique role of each ligand in the function of HPPD, and which correlates with their respective co-ordination position. PMID: 26936969
    2. 4-hydroxyphenylpyruvate dioxygenase gene mutation is associated with Hawkinsinuria. PMID: 26226126
    3. Glutamine375 has a critical role for 4-HPPD in orientating the tail and ensuring the conformation of the terminal alpha-helix of the enzyme to maintain the integrity of the active site for biocatalysis. PMID: 23950902
    4. The IIe335Met allele is equivalent to a null mutation while the Asn241Ser allele results in a partially active enzyme with an uncoupled turnover causing elevated haykinin in urine. PMID: 17560158
  • 相关疾病：
    Tyrosinemia 3 (TYRSN3); Hawkinsinuria (HAWK)
  • 蛋白家族：
    4HPPD family
  • 数据库链接：

    HGNC: 5147

    OMIM: 140350

    KEGG: hsa:3242

    STRING: 9606.ENSP00000289004

    UniGene: Hs.2899