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KATNB1 Antibody

  • 中文名称：
    KATNB1兔多克隆抗体
  • 货号：
    CSB-PA011993GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BVA0
  • 基因名：
    KATNB1
  • 别名：
    KAT antibody; Katanin (80 kDa) antibody; Katanin p80 (WD repeat containing) subunit B 1 antibody; Katanin p80 subunit B 1 antibody; Katanin p80 subunit B1 antibody; Katanin p80 WD40-containing subunit B1 antibody; katnb1 antibody; KTNB1_HUMAN antibody; OTTHUMP00000164672 antibody; p80 katanin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KATNB1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
  • 基因功能参考文献：
    1. these findings provide valuable insights into the pathogenesis of severe microlissencephaly, in which p80 and NuMA delineate a common pathway for neurogenesis and neuronal migration via microtubule organization at the centrosome/spindle pole PMID: 28079116
    2. ASPM-katanin complex controls microtubule disassembly at spindle poles and that misregulation of this process can lead to microcephaly. PMID: 28436967
    3. Results indicate that microtubule-severing is complex and likely regulated by the concerted action of KATNB1 and KATNBL1. PMID: 26929214
    4. The localization of KATNB1 in early round spermatids suggests an involvement in the formation of microtubule-based structures during spermiogenesis (manchette and flagellum). PMID: 27717557
    5. results suggest that variants in the KATNB1 gene are not commonly associated with OAT infertility in Australian men PMID: 25280067
    6. results provide insight into the mechanisms by which KATNB1 mutations cause human cerebral cortical malformations, demonstrating its fundamental role during brain development. PMID: 25521378
    7. results reveal unexpected functions for KATNB1 in regulating overall centriole, mother centriole, and cilia number, and as an essential gene for normal Hedgehog signaling during neocortical development PMID: 25521379
    8. LAPSER1 C terminal domain inhibits katanin(p80/p60)-mediated microtubule severing in vitro. PMID: 18490357
    9. Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal PMID: 19261606

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  • 相关疾病：
    Lissencephaly 6, with microcephaly (LIS6)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    WD repeat KATNB1 family
  • 数据库链接：

    HGNC: 6217

    OMIM: 602703

    KEGG: hsa:10300

    STRING: 9606.ENSP00000368982

    UniGene: Hs.275675