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KDM1B Antibody

  • 货号：
    CSB-PA822748LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA822748LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA822748LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KDM1B Polyclonal antibody
  • Uniprot No.：
    Q8NB78
  • 基因名：
    KDM1B
  • 别名：
    amine oxidase (flavin containing) domain 1 antibody; amine oxidase, flavin containing 1 antibody; AOF1 antibody; bA204B7.3 antibody; C6orf193 antibody; dJ298J15.2 antibody; Flavin-containing amine oxidase domain-containing protein 1 antibody; FLJ33898 antibody; FLJ34109 antibody; FLJ43328 antibody; KDM1B antibody; KDM1B_HUMAN antibody; LSD2 antibody; lysine (K)-specific demethylase 1B antibody; Lysine-specific demethylase 2 antibody; Lysine-specific histone demethylase 1B antibody; Lysine-specific histone demethylase 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Lysine-specific histone demethylase 1B protein (451-544AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KDM1B Antibody (CSB-PA822748LA01HU)，的标记方式是Non-conjugated。对于KDM1B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA822748LB01HU KDM1B Antibody, HRP conjugated ELISA
    FITC CSB-PA822748LC01HU KDM1B Antibody, FITC conjugated
    Biotin CSB-PA822748LD01HU KDM1B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.
  • 基因功能参考文献：
    1. These results suggest that LSD2 achieves a promoting effect on small cell lung cancer by indirectly regulating TFPI2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPI2 gene. PMID: 29845195
    2. This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes. PMID: 28277979
    3. These results demonstrate an important role for LSD2 in regulation of DNA methylation and gene silencing in breast cancer. PMID: 24924415
    4. Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT. PMID: 25773598
    5. Using transcriptome and chromatin immunoprecipitation-sequencing analyses, the study revealed that LSD2 represses the genes involved in lipid influx and metabolism through demethylation of histone H3K4. PMID: 25624347
    6. regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 PMID: 25036127
    7. The zinc finger-SWIRM-oxidase domains is required for KDM1B demethylase activity and the binding of FAD. PMID: 23266887
    8. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. PMID: 20670891

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 数据库链接：

    HGNC: 21577

    OMIM: 613081

    KEGG: hsa:221656

    STRING: 9606.ENSP00000297792

    UniGene: Hs.709336