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KHSRP Antibody

  • 货号：
    CSB-PA002508
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Hela cells using FBP2 Polyclonal Antibody
    • Western Blot analysis of Jurkat cells using FBP2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q92945
  • 基因名：
    KHSRP
  • 别名：
    Far upstream element-binding protein 2 antibody; FBP2 antibody; FUBP2 antibody; FUBP2_HUMAN antibody; FUSE binding protein 2 antibody; FUSE-binding protein 2 antibody; KH type splicing regulatory protein (FUSE binding protein 2) antibody; KH type splicing regulatory protein antibody; KH type-splicing regulatory protein antibody; KHSRP antibody; KSRP antibody; p75 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human FBP2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
  • 基因功能参考文献：
    1. KSRP, miR-129, and RUNX1 participate in a regulatory axis to control the outcome of myeloid differentiation. PMID: 29127290
    2. The s find that KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA). PMID: 28248290
    3. we discovered a novel mechanism underlying SUMOylation of KHSRP regulating the production of some special miRNAs. PMID: 29020972
    4. KSRP decreased EGR3 mRNA stability in an ARE-independent manner. PMID: 28847731
    5. TGF-beta-induced KHSRP silencing is central in a pathway leading to gene-expression. PMID: 27396342
    6. mechanistic evidence that KSRP promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation. PMID: 28275056
    7. The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells. PMID: 27899653
    8. The miRNA biogenesis factors, DDX17 and KHSRP, regulate the protein level of Ago2 in human cells. PMID: 27478153
    9. Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis. PMID: 27573585
    10. High FBP2 expression is associated with doxorubicin resistance in breast cancer . PMID: 26810065
    11. Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells PMID: 27644194
    12. The expression of KSRP in liver epithelial cells controlled by mir-27b. PMID: 26631623
    13. Khsrp as a highly regulated RBP in response to genotoxic stress. PMID: 25993413
    14. The ability of KSRP to integrate different levels of gene expression is required for proper immune response. [Review] PMID: 24845017
    15. subcellular localization of KSRP is regulated by competing interactions with DDX1 or 14-3-3 PMID: 24023901
    16. KSRP induces enhanced processing of pri- and pre-miR-155 in cystic fibrosis lung epithelial cells. PMID: 23524258
    17. Enterovirus 71 infection cleaved FBP2, which altered its function when its carboxyl terminus was cleaved. PMID: 23345520
    18. Binding of the human KSRP protein to let-7 miRNA precursors positively regulates their processing to mature let-7, thereby contributing to control of cell proliferation, apoptosis and differentiation PMID: 23142982
    19. The role of KSRP in mRNA decay and microRNA precursor maturation. PMID: 21935887
    20. RACK1 binds to KH-type splicing regulatory protein (KSRP), a member of the Dicer complex, and is required for the recruitment of mature miRNAs to the RNA-induced silencing complex (RISC). PMID: 21935400
    21. KHSRP was identified as being involved in the regulation of rpL3 gene expression via alternative pre-mRNA splicing. PMID: 21705779
    22. KSRP-dependent silencing was reversed by IL-1, a strong inducer of IL-6 mRNA and protein expression. PMID: 21795706
    23. KSRP binds to the terminal loop sequence of a subset of miRNA precursors promoting their maturation (REVIEW) PMID: 21627028
    24. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors[review] PMID: 21196264
    25. hnRNP A1 and KSRP have antagonistic roles in the post-transcriptional regulation of let-7a expression. PMID: 20639884
    26. Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability. PMID: 20332102
    27. KSRP do indeed interact with the c-src transcript in vivo, and that these associations change with the differentiated state of the cell. PMID: 14657238
    28. KSRP, a KH domain-containing ARE-BP, is an essential factor for ARE-directed mRNA decay. Some KH motifs of KSRP mediate RNA binding, mRNA decay, and interactions with the exosome. PMID: 15175153
    29. IL-8 RNA from IL-1beta-stimulated cytoplasmic extract revealed a 20-fold greater association of transcript with the stabilizing factor HuR vs. the destabilizing factor KSRP in breast cancer cells PMID: 15514971
    30. KHSRP, tethered to mRNAs, elicits mRNA decay. PMID: 16648466
    31. These results indicate that KSRP functions as a limiting factor in inflammatory gene expression. PMID: 17908789
    32. These data indicate a novel role for KSRP in parathyroid hormone gene expression. PMID: 18583400
    33. The over-expression of a novel protein family, far upstream binding proteins (FUBPs) was identified in both stages of hepatocellular carcinoma and confirmed by western blots. PMID: 19003864
    34. KSRP serves as a component of both Drosha and Dicer complexes and regulates the biogenesis of a subset of miRNAs PMID: 19458619
    35. The coordinated activation of FBP-1 and FBP-2 represents a novel and frequent pro-tumorigenic mechanism promoting proliferation (tumor growth) and motility (dissemination) of human liver cancer cells. PMID: 19585652
    36. Knock-down of either exosome components or KSRP by siRNAs prevents PMR1-mediated cleavage of PTH mRNA. PMID: 19775426

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    KHSRP family
  • 组织特异性：
    Detected in neural and non-neural cell lines.
  • 数据库链接：

    HGNC: 6316

    OMIM: 603445

    KEGG: hsa:8570

    STRING: 9606.ENSP00000381216

    UniGene: Hs.727344