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  4. Recombinant Human Far upstream element-binding protein 2 (KHSRP)

Recombinant Human Far upstream element-binding protein 2 (KHSRP)

  • 中文名称：
    人KHSRP重组蛋白
  • 货号：
    CSB-YP821716HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KHSRP重组蛋白
  • 货号：
    CSB-EP821716HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KHSRP重组蛋白
  • 货号：
    CSB-EP821716HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KHSRP重组蛋白
  • 货号：
    CSB-BP821716HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KHSRP重组蛋白
  • 货号：
    CSB-MP821716HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KHSRP
  • Uniprot No.：
  • 别名：
    Far upstream element-binding protein 2; FBP2; FUBP2; FUBP2_HUMAN; FUSE binding protein 2; FUSE-binding protein 2; KH type splicing regulatory protein (FUSE binding protein 2); KH type splicing regulatory protein; KH type-splicing regulatory protein; KHSRP; KSRP; p75
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-711
  • 氨基酸序列
    SDYSTGGPP PGPPPPAGGG GGAGGAGGGP PPGPPGAGDR GGGGPGGGGP GGGSAGGPSQ PPGGGGPGIR KDAFADAVQR ARQIAAKIGG DAATTVNNST PDFGFGGQKR QLEDGDQPES KKLASQGDSI SSQLGPIHPP PRTSMTEEYR VPDGMVGLII GRGGEQINKI QQDSGCKVQI SPDSGGLPER SVSLTGAPES VQKAKMMLDD IVSRGRGGPP GQFHDNANGG QNGTVQEIMI PAGKAGLVIG KGGETIKQLQ ERAGVKMILI QDGSQNTNVD KPLRIIGDPY KVQQACEMVM DILRERDQGG FGDRNEYGSR IGGGIDVPVP RHSVGVVIGR SGEMIKKIQN DAGVRIQFKQ DDGTGPEKIA HIMGPPDRCE HAARIINDLL QSLRSGPPGP PGGPGMPPGG RGRGRGQGNW GPPGGEMTFS IPTHKCGLVI GRGGENVKAI NQQTGAFVEI SRQLPPNGDP NFKLFIIRGS PQQIDHAKQL IEEKIEGPLC PVGPGPGGPG PAGPMGPFNP GPFNQGPPGA PPHAGGPPPH QYPPQGWGNT YPQWQPPAPH DPSKAAAAAA DPNAAWAAYY SHYYQQPPGP VPGPAPAPAA PPAQGEPPQP PPTGQSDYTK AWEEYYKKIG QQPQQPGAPP QQDYTKAWEE YYKKQAQVAT GGGPGAPPGS QPDYSAAWAE YYRQQAAYYG QTPGPGGPQP PPTQQGQQQA Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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靶点详情

  • 功能：
    Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
  • 基因功能参考文献：
    1. KSRP, miR-129, and RUNX1 participate in a regulatory axis to control the outcome of myeloid differentiation. PMID: 29127290
    2. The s find that KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA). PMID: 28248290
    3. we discovered a novel mechanism underlying SUMOylation of KHSRP regulating the production of some special miRNAs. PMID: 29020972
    4. KSRP decreased EGR3 mRNA stability in an ARE-independent manner. PMID: 28847731
    5. TGF-beta-induced KHSRP silencing is central in a pathway leading to gene-expression. PMID: 27396342
    6. mechanistic evidence that KSRP promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation. PMID: 28275056
    7. The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells. PMID: 27899653
    8. The miRNA biogenesis factors, DDX17 and KHSRP, regulate the protein level of Ago2 in human cells. PMID: 27478153
    9. Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis. PMID: 27573585
    10. High FBP2 expression is associated with doxorubicin resistance in breast cancer . PMID: 26810065
    11. Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells PMID: 27644194
    12. The expression of KSRP in liver epithelial cells controlled by mir-27b. PMID: 26631623
    13. Khsrp as a highly regulated RBP in response to genotoxic stress. PMID: 25993413
    14. The ability of KSRP to integrate different levels of gene expression is required for proper immune response. [Review] PMID: 24845017
    15. subcellular localization of KSRP is regulated by competing interactions with DDX1 or 14-3-3 PMID: 24023901
    16. KSRP induces enhanced processing of pri- and pre-miR-155 in cystic fibrosis lung epithelial cells. PMID: 23524258
    17. Enterovirus 71 infection cleaved FBP2, which altered its function when its carboxyl terminus was cleaved. PMID: 23345520
    18. Binding of the human KSRP protein to let-7 miRNA precursors positively regulates their processing to mature let-7, thereby contributing to control of cell proliferation, apoptosis and differentiation PMID: 23142982
    19. The role of KSRP in mRNA decay and microRNA precursor maturation. PMID: 21935887
    20. RACK1 binds to KH-type splicing regulatory protein (KSRP), a member of the Dicer complex, and is required for the recruitment of mature miRNAs to the RNA-induced silencing complex (RISC). PMID: 21935400
    21. KHSRP was identified as being involved in the regulation of rpL3 gene expression via alternative pre-mRNA splicing. PMID: 21705779
    22. KSRP-dependent silencing was reversed by IL-1, a strong inducer of IL-6 mRNA and protein expression. PMID: 21795706
    23. KSRP binds to the terminal loop sequence of a subset of miRNA precursors promoting their maturation (REVIEW) PMID: 21627028
    24. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors[review] PMID: 21196264
    25. hnRNP A1 and KSRP have antagonistic roles in the post-transcriptional regulation of let-7a expression. PMID: 20639884
    26. Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability. PMID: 20332102
    27. KSRP do indeed interact with the c-src transcript in vivo, and that these associations change with the differentiated state of the cell. PMID: 14657238
    28. KSRP, a KH domain-containing ARE-BP, is an essential factor for ARE-directed mRNA decay. Some KH motifs of KSRP mediate RNA binding, mRNA decay, and interactions with the exosome. PMID: 15175153
    29. IL-8 RNA from IL-1beta-stimulated cytoplasmic extract revealed a 20-fold greater association of transcript with the stabilizing factor HuR vs. the destabilizing factor KSRP in breast cancer cells PMID: 15514971
    30. KHSRP, tethered to mRNAs, elicits mRNA decay. PMID: 16648466
    31. These results indicate that KSRP functions as a limiting factor in inflammatory gene expression. PMID: 17908789
    32. These data indicate a novel role for KSRP in parathyroid hormone gene expression. PMID: 18583400
    33. The over-expression of a novel protein family, far upstream binding proteins (FUBPs) was identified in both stages of hepatocellular carcinoma and confirmed by western blots. PMID: 19003864
    34. KSRP serves as a component of both Drosha and Dicer complexes and regulates the biogenesis of a subset of miRNAs PMID: 19458619
    35. The coordinated activation of FBP-1 and FBP-2 represents a novel and frequent pro-tumorigenic mechanism promoting proliferation (tumor growth) and motility (dissemination) of human liver cancer cells. PMID: 19585652
    36. Knock-down of either exosome components or KSRP by siRNAs prevents PMR1-mediated cleavage of PTH mRNA. PMID: 19775426

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    KHSRP family
  • 组织特异性：
    Detected in neural and non-neural cell lines.
  • 数据库链接：

    HGNC: 6316

    OMIM: 603445

    KEGG: hsa:8570

    STRING: 9606.ENSP00000381216

    UniGene: Hs.727344