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KIF15 Antibody

  • 货号：
    CSB-PA868310LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA868310LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KIF15 Polyclonal antibody
  • Uniprot No.：
    Q9NS87
  • 基因名：
    KIF15
  • 别名：
    KIF15 antibody; KLP2 antibody; KNSL7Kinesin-like protein KIF15 antibody; Kinesin-like protein 2 antibody; hKLP2 antibody; Kinesin-like protein 7 antibody; Serologically defined breast cancer antigen NY-BR-62 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Kinesin-like protein KIF15 protein (1-129AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KIF15 Antibody (CSB-PA868310LA01HU)，的标记方式是Non-conjugated。对于KIF15 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA868310LB01HU KIF15 Antibody, HRP conjugated ELISA
    FITC CSB-PA868310LC01HU KIF15 Antibody, FITC conjugated
    Biotin CSB-PA868310LD01HU KIF15 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.
  • 基因功能参考文献：
    1. KIF15 knockdown using short hairpin RNA in two human lung adenocarcinoma cell lines induced G1/S phase cell cycle arrest and inhibited cell growth. PMID: 30439711
    2. The non-motor microtubule-binding tail domain interacts with the microtubule's E-hook tail with a rupture force higher than the stall force of the motor. This allows Kif15 dimers to productively and efficiently generate forces that could potentially slide microtubules apart. PMID: 28918951
    3. Both Kif15 and KBP are required for the alignment of all the chromosomes to the metaphase plate and the assembly of stable kinetochore fibers of the correct length. PMID: 28445502
    4. This study identified KIF15 as a critical regulator that promotes pancreatic cancer proliferation, broadening our understanding of KIF15 function in tumorigenesis. PMID: 28595260
    5. To our knowledge, KIF15 is the first kinesin to be associated with congenital thrombocytopenia. PMID: 28150392
    6. KIF15 is involved in alternative spindle assembly pathways. PMID: 27091450
    7. When intersecting microtubules are parallel, Kif15 motors can drive (biased) parallel sliding because the motor simultaneously steps on both microtubules that it cross-links. PMID: 26969727
    8. These data reveal that hKif15 is a plus-end-directed processive homotetramer that can step against loads of up to 3.5 pN. PMID: 24668168
    9. Eg5, Kif15, and dynein work together to build a bipolar spindle and reveal an important role for antagonistic motors in chromosome segregation. PMID: 25127142
    10. regulates alpha2 integrin internalization PMID: 24659801
    11. Although Kif15 contains ADP in the catalytic site, its motor-domain structure was captured in the ;ATP-like' configuration, with the neck linker docked to the catalytic core. PMID: 24419385
    12. By examining Kif15 activity in two cellular contexts, it was found that Kif15 bound to kinetochore fibers antagonizes centrosome separation while Kif15 bound to nonkinetochore MTs mediates centrosome separation. PMID: 23791727
    13. Pole separation depends on Hklp2/Kif15, an otherwise dispensable plus end-directed spindle motor and results in spindles with two centrosomal poles. PMID: 22024925
    14. Kif15 can replace all essential functions of Eg5 in bipolar spindle assembly. PMID: 19818618
    15. Hklp2 participates in the assembly and stabilization of the bipolar spindle. PMID: 19818619

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KLP2 subfamily
  • 组织特异性：
    Expressed in testis, colon, thymus and in breast cancer.
  • 数据库链接：

    HGNC: 17273

    OMIM: 617569

    KEGG: hsa:56992

    STRING: 9606.ENSP00000324020

    UniGene: Hs.658939