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LAS1L Antibody

  • 货号：
    CSB-PA897285LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate
      All lanes: LAS1L antibody at 3.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 84, 82, 77, 34 kDa
      Observed band size: 84 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA897285LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LAS1L Polyclonal antibody
  • Uniprot No.：
    Q9Y4W2
  • 基因名：
    LAS1L
  • 别名：
    dJ475B7.2 antibody; FLJ12525 antibody; FLJ30133 antibody; FLJ45274 antibody; LAS1 like (S. cerevisiae) antibody; Las1 like antibody; LAS1L antibody; LAS1L_HUMAN antibody; Protein LAS1 homolog antibody; Ribosomal biogenesis protein LAS1L antibody; RP3 475B7.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ribosomal biogenesis protein LAS1L protein (490-565AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LAS1L Antibody (CSB-PA897285LA01HU)，的标记方式是Non-conjugated。对于LAS1L Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA897285LB01HU LAS1L Antibody, HRP conjugated ELISA
    FITC CSB-PA897285LC01HU LAS1L Antibody, FITC conjugated
    Biotin CSB-PA897285LD01HU LAS1L Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
  • 基因功能参考文献：
    1. LAS1L interacts with PELP1, TEX10, and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit. PMID: 22190735
    2. Analysis of high-molecular-weight RNAs confirmed that Las1L is required for ITS2 processing,which separates the 5.8S and 25S/28S rRNAs, as 32S was found to accumulate and 12S to diminish upon Las1L depletion. PMID: 22083961
    3. Data demonstrate that Las1L is essential for cell proliferation and biogenesis of the 60S ribosomal subunit. PMID: 20647540
  • 相关疾病：
    Wilson-Turner X-linked mental retardation syndrome (WTS)
  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm.
  • 蛋白家族：
    LAS1 family
  • 数据库链接：

    HGNC: 25726

    OMIM: 300964

    KEGG: hsa:81887

    STRING: 9606.ENSP00000363944

    UniGene: Hs.522675