Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Ribosomal biogenesis protein LAS1L (LAS1L)

Recombinant Human Ribosomal biogenesis protein LAS1L (LAS1L)

  • 中文名称：
    人LAS1L重组蛋白
  • 货号：
    CSB-YP897285HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LAS1L重组蛋白
  • 货号：
    CSB-EP897285HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LAS1L重组蛋白
  • 货号：
    CSB-EP897285HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LAS1L重组蛋白
  • 货号：
    CSB-BP897285HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LAS1L重组蛋白
  • 货号：
    CSB-MP897285HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LAS1L
  • Uniprot No.：
  • 别名：
    dJ475B7.2; FLJ12525; FLJ30133; FLJ45274; LAS1 like (S. cerevisiae); Las1 like; LAS1L; LAS1L_HUMAN; Protein LAS1 homolog; Ribosomal biogenesis protein LAS1L; RP3 475B7.2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-734
  • 氨基酸序列
    MSWESGAGPG LGSQGMDLVW SAWYGKCVKG KGSLPLSAHG IVVAWLSRAE WDQVTVYLFC DDHKLQRYAL NRITVWRSRS GNELPLAVAS TADLIRCKLL DVTGGLGTDE LRLLYGMALV RFVNLISERK TKFAKVPLKC LAQEVNIPDW IVDLRHELTH KKMPHINDCR RGCYFVLDWL QKTYWCRQLE NSLRETWELE EFREGIEEED QEEDKNIVVD DITEQKPEPQ DDGKSTESDV KADGDSKGSE EVDSHCKKAL SHKELYERAR ELLVSYEEEQ FTVLEKFRYL PKAIKAWNNP SPRVECVLAE LKGVTCENRE AVLDAFLDDG FLVPTFEQLA ALQIEYEDGQ TEVQRGEGTD PKSHKNVDLN DVLVPKPFSQ FWQPLLRGLH SQNFTQALLE RMLSELPALG ISGIRPTYIL RWTVELIVAN TKTGRNARRF SAGQWEARRG WRLFNCSASL DWPRMVESCL GSPCWASPQL LRIIFKAMGQ GLPDEEQEKL LRICSIYTQS GENSLVQEGS EASPIGKSPY TLDSLYWSVK PASSSFGSEA KAQQQEEQGS VNDVKEEEKE EKEVLPDQVE EEEENDDQEE EEEDEDDEDD EEEDRMEVGP FSTGQESPTA ENARLLAQKR GALQGSAWQV SSEDVRWDTF PLGRMPGQTE DPAELMLENY DTMYLLDQPV LEQRLEPSTC KTDTLGLSCG VGSGNCSNSS SSNFEGLLWS QGQLHGLKTG LQLF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
  • 基因功能参考文献：
    1. LAS1L interacts with PELP1, TEX10, and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit. PMID: 22190735
    2. Analysis of high-molecular-weight RNAs confirmed that Las1L is required for ITS2 processing,which separates the 5.8S and 25S/28S rRNAs, as 32S was found to accumulate and 12S to diminish upon Las1L depletion. PMID: 22083961
    3. Data demonstrate that Las1L is essential for cell proliferation and biogenesis of the 60S ribosomal subunit. PMID: 20647540
  • 相关疾病：
    Wilson-Turner X-linked mental retardation syndrome (WTS)
  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm.
  • 蛋白家族：
    LAS1 family
  • 数据库链接：

    HGNC: 25726

    OMIM: 300964

    KEGG: hsa:81887

    STRING: 9606.ENSP00000363944

    UniGene: Hs.522675