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LBH Antibody

  • 货号：
    CSB-PA700659LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of Hela cells using CSB-PA700659LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LBH Polyclonal antibody
  • Uniprot No.：
    Q53QV2
  • 基因名：
    LBH
  • 别名：
    hLBH antibody; lbh antibody; LBH_HUMAN antibody; Limb bud and heart development antibody; Limb bud and heart development homolog (mouse) antibody; Protein LBH antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein LBH protein (1-105AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LBH Antibody (CSB-PA700659LA01HU)，的标记方式是Non-conjugated。对于LBH Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA700659LB01HU LBH Antibody, HRP conjugated ELISA
    FITC CSB-PA700659LC01HU LBH Antibody, FITC conjugated
    Biotin CSB-PA700659LD01HU LBH Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
  • 基因功能参考文献：
    1. LBH was significantly down-regulated in lung cancer tissue samples and was correlated with the prognosis and clinical characteristics of lung cancer patients. Survival analysis revealed that LBH-negative expression was associated with poor overall survival of LUAD patients (P = 0.021). PMID: 29788015
    2. Low LBH level, caused by a rheumatoid arthritis risk allele, is a risk factor for aggressive fibroblast-like synoviocyte behavior. PMID: 27159840
    3. The expression levels of LBH mRNA in patients with SLE were significantly decreased compared with those in normal controls (P < 0.001). No significant differences were found between LBH mRNA expression levels and SLE disease activity scores, SNP rs7579944 and rs906868. PMID: 26134586
    4. LBH normally induces NPC cell cycle arrest at the G1/S transition, and LBH can suppress the growth of transplanted NPC tumors in vivo by downregulating LMP1-mediated NF-kappaB transcriptional activity. PMID: 25557837
    5. LBH is a candidate gene for synovial pathology in rheumatoid arthritis. It is regulated by growth factors and modulates cell growth in primary fibroblast-like synoviocytes. PMID: 25707478
    6. results showed that the interaction of LBH and alphaB-crystallin may inhibit synergistically the transcriptional regulation of p53 and p21 PMID: 20587334
    7. LBH is aberrantly overexpressed in mammary tumors of mouse mammary tumor virus (MMTV)-Wnt1-transgenic mice and in aggressive basal subtype human breast cancers that display Wnt/beta-catenin hyperactivation. PMID: 20606007
    8. LBH is implicated as a candidate gene for congenital heart disease associated with partial trisomy 2p syndrome PMID: 15958514
    9. These results suggest that hLBH proteins may act as a transcriptional activator in mitogen-activated protein kinase signaling pathway to mediate cellular functions. PMID: 17390236

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    LBH family
  • 组织特异性：
    Highly expressed in heart, and expressed at low levels in placenta, lung, skeletal muscle, kidney and liver.
  • 数据库链接：

    HGNC: 29532

    OMIM: 611763

    KEGG: hsa:81606

    STRING: 9606.ENSP00000378733

    UniGene: Hs.567598