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  4. Recombinant Human Protein LBH (LBH)

Recombinant Human Protein LBH (LBH)

  • 货号：
    CSB-YP700659HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP700659HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP700659HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP700659HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP700659HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LBH
  • Uniprot No.：
  • 别名：
    hLBH; lbh; LBH_HUMAN; Limb bud and heart development; Limb bud and heart development homolog (mouse) ; Protein LBH
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-105
  • 氨基酸序列
    MSIYFPIHCP DYLRSAKMTE VMMNTQPMEE IGLSPRKDGL SYQIFPDPSD FDRCCKLKDR LPSIVVEPTE GEVESGELRW PPEEFLVQED EQDNCEETAK ENKEQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
  • 基因功能参考文献：
    1. LBH was significantly down-regulated in lung cancer tissue samples and was correlated with the prognosis and clinical characteristics of lung cancer patients. Survival analysis revealed that LBH-negative expression was associated with poor overall survival of LUAD patients (P = 0.021). PMID: 29788015
    2. Low LBH level, caused by a rheumatoid arthritis risk allele, is a risk factor for aggressive fibroblast-like synoviocyte behavior. PMID: 27159840
    3. The expression levels of LBH mRNA in patients with SLE were significantly decreased compared with those in normal controls (P < 0.001). No significant differences were found between LBH mRNA expression levels and SLE disease activity scores, SNP rs7579944 and rs906868. PMID: 26134586
    4. LBH normally induces NPC cell cycle arrest at the G1/S transition, and LBH can suppress the growth of transplanted NPC tumors in vivo by downregulating LMP1-mediated NF-kappaB transcriptional activity. PMID: 25557837
    5. LBH is a candidate gene for synovial pathology in rheumatoid arthritis. It is regulated by growth factors and modulates cell growth in primary fibroblast-like synoviocytes. PMID: 25707478
    6. results showed that the interaction of LBH and alphaB-crystallin may inhibit synergistically the transcriptional regulation of p53 and p21 PMID: 20587334
    7. LBH is aberrantly overexpressed in mammary tumors of mouse mammary tumor virus (MMTV)-Wnt1-transgenic mice and in aggressive basal subtype human breast cancers that display Wnt/beta-catenin hyperactivation. PMID: 20606007
    8. LBH is implicated as a candidate gene for congenital heart disease associated with partial trisomy 2p syndrome PMID: 15958514
    9. These results suggest that hLBH proteins may act as a transcriptional activator in mitogen-activated protein kinase signaling pathway to mediate cellular functions. PMID: 17390236

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    LBH family
  • 组织特异性：
    Highly expressed in heart, and expressed at low levels in placenta, lung, skeletal muscle, kidney and liver.
  • 数据库链接：

    HGNC: 29532

    OMIM: 611763

    KEGG: hsa:81606

    STRING: 9606.ENSP00000378733

    UniGene: Hs.567598