Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. LILRA3 Antibody

LILRA3 Antibody

  • 货号：
    CSB-PA836677LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, Jurkat whole cell lysate
      All lanes: LILRA3 antibody at 4.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 48, 41, 50 kDa
      Observed band size: 48 kDa
    • IHC image of CSB-PA836677LA01HU diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LILRA3 Polyclonal antibody
  • Uniprot No.：
    Q8N6C8
  • 基因名：
  • 别名：
    CD 85E antibody; CD85 antigen-like family member E antibody; CD85e antibody; CD85e antigen antibody; e3 antibody; HM 31 antibody; HM 43 antibody; HM31 antibody; HM43 antibody; ILT 6 antibody; ILT-6 antibody; ILT6 antibody; Immunoglobulin like transcript 6 antibody; Immunoglobulin-like transcript 6 antibody; Leucocyte immunoglobulin like receptor antibody; Leukocyte immunoglobulin like receptor 4 antibody; Leukocyte immunoglobulin like receptor A3 antibody; Leukocyte immunoglobulin like receptor subfamily A (without TM domain) member 3 antibody; Leukocyte immunoglobulin like receptor subfamily A member 3 antibody; Leukocyte immunoglobulin-like receptor 4 antibody; Leukocyte immunoglobulin-like receptor subfamily A member 3 antibody; LILRA 3 antibody; LILRA3 antibody; LIR 4 antibody; LIR-4 antibody; LIR4 antibody; LIRA3_HUMAN antibody; Monocyte inhibitory receptor HM43/HM31 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 3 protein (222-313AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LILRA3 Antibody (CSB-PA836677LA01HU)，的标记方式是Non-conjugated。对于LILRA3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836677LB01HU LILRA3 Antibody, HRP conjugated ELISA
    FITC CSB-PA836677LC01HU LILRA3 Antibody, FITC conjugated
    Biotin CSB-PA836677LD01HU LILRA3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
  • 基因功能参考文献：
    1. Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc. PMID: 24891332
    2. The homozygous LILRA3 deletion is associated with a higher susceptibility for HIV disease and with a faster disease progression. PMID: 27755104
    3. Letter: LILRA3 gene deletion is not involved in the giant cell arteritis and systemic sclerosis predisposition in Spanish patients. PMID: 27462831
    4. LILRA3 significantly reversed Nogo-66-mediated inhibition of neurite outgrowth and promoted synapse formation in primary cortical neurons through regulation of the ERK/MEK pathway. PMID: 26826187
    5. Experiments point towards a beneficial role for LILRA3 in virus infections, especially in ssRNA viruses, like HIV, that engage TLR8; however, the potentially beneficial role of LILRA3 is abrogated during a HIV infection. PMID: 26969150
    6. LILRA3 gene deletion was not associated with Multiple Sclerosis susceptibility and did not affect the age of disease onset, clinical subtype or disease severity. PMID: 26871720
    7. Evidence showed lack of significant association between LILRA3 deletion and multiple sclerosis pathogenesis. [meta-analysis] PMID: 26274821
    8. LILRA3 is a new susceptibility factor for systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS). It predisposes to certain phenotypes such as leucopenia, thrombocytopenia, autoantibody positivity and increased disease activity. PMID: 24906639
    9. The current study was conducted to investigate the association of rs103294 of LILRA3 with benign prostatic hyperplasia risk. PMID: 23615473
    10. ILT6 deletion polymorphism does not appear to be a lupus susceptibility gene in South Indian Tamils, but may behave as a genetic modifier of autoantibody phenotype by influencing the production of anti-Ro60 and anti-Ro52 autoantibodies PMID: 24899637
    11. LILRA3 is an immunostimulatory molecule, whose deficiency is associated with higher frequency of B-non-Hodgkin's lymphoma. PMID: 24363809
    12. functional LILRA3 is a novel genetic risk factor for rheumatoid arthritis (RA), especially in males. It appears to highly predispose to ACPA-positive RA and confers an increased risk of disease severity in patients with early RA. PMID: 24757135
    13. Data did not indicate any association of LILRA3 deletion with multiple sclerosis (MS) susceptibility, however, patients negative for the deletion may begin to suffer from MS significantly earlier than patients who are positive. PMID: 23238213
    14. LILRA1 and LILRA3 generally display a greater binding preference for binding to HLA-C free heavy chain, particularly following removal of beta2-microglobulin by acid treatment. PMID: 21270408
    15. These results suggest that LILRA3 may play a role in chronic inflammatory conditions such as rheumatoid arthritis. PMID: 20595277
    16. A deletion of LILRA3 gene was found in a minority of British population PMID: 12651072
    17. Six alleles characterised, of which four will encode unique peptides, one of which is likely to directly influence ligand binding. PMID: 12750859
    18. Multiple sclerosis associates with LILRA3 deletion. PMID: 19421224
    19. ILT6 deficiency may be a genetic risk factor for Sjogren's syndrome. PMID: 19790059

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.
  • 数据库链接：

    HGNC: 6604

    OMIM: 604818

    KEGG: hsa:11026

    STRING: 9606.ENSP00000251390

    UniGene: Hs.113277