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  4. Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3)

Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3)

  • 货号：
    CSB-YP836677HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP836677HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP836677HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP836677HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP836677HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CD 85E; CD85 antigen-like family member E; CD85e; CD85e antigen; e3; HM 31; HM 43; HM31; HM43; ILT 6; ILT-6; ILT6; Immunoglobulin like transcript 6; Immunoglobulin-like transcript 6; Leucocyte immunoglobulin like receptor; Leukocyte immunoglobulin like receptor 4; Leukocyte immunoglobulin like receptor A3; Leukocyte immunoglobulin like receptor subfamily A (without TM domain) member 3; Leukocyte immunoglobulin like receptor subfamily A member 3; Leukocyte immunoglobulin-like receptor 4; Leukocyte immunoglobulin-like receptor subfamily A member 3; LILRA 3; LILRA3; LIR 4; LIR-4; LIR4; LIRA3_HUMAN; Monocyte inhibitory receptor HM43/HM31
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-439
  • 氨基酸序列
    GPLPKPT LWAEPGSVIT QGSPVTLRCQ GSLETQEYHL YREKKTALWI TRIPQELVKK GQFPILSITW EHAGRYCCIY GSHTAGLSES SDPLELVVTG AYSKPTLSAL PSPVVTSGGN VTIQCDSQVA FDGFILCKEG EDEHPQCLNS HSHARGSSRA IFSVGPVSPS RRWSYRCYGY DSRAPYVWSL PSDLLGLLVP GVSKKPSLSV QPGPVVAPGE KLTFQCGSDA GYDRFVLYKE WGRDFLQRPG RQPQAGLSQA NFTLGPVSRS YGGQYTCSGA YNLSSEWSAP SDPLDILITG QIRARPFLSV RPGPTVASGE NVTLLCQSQG GMHTFLLTKE GAADSPLRLK SKRQSHKYQA EFPMSPVTSA HAGTYRCYGS LSSNPYLLTH PSDPLELVVS GAAETLSPPQ NKSDSKAGE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
  • 基因功能参考文献：
    1. Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc. PMID: 24891332
    2. The homozygous LILRA3 deletion is associated with a higher susceptibility for HIV disease and with a faster disease progression. PMID: 27755104
    3. Letter: LILRA3 gene deletion is not involved in the giant cell arteritis and systemic sclerosis predisposition in Spanish patients. PMID: 27462831
    4. LILRA3 significantly reversed Nogo-66-mediated inhibition of neurite outgrowth and promoted synapse formation in primary cortical neurons through regulation of the ERK/MEK pathway. PMID: 26826187
    5. Experiments point towards a beneficial role for LILRA3 in virus infections, especially in ssRNA viruses, like HIV, that engage TLR8; however, the potentially beneficial role of LILRA3 is abrogated during a HIV infection. PMID: 26969150
    6. LILRA3 gene deletion was not associated with Multiple Sclerosis susceptibility and did not affect the age of disease onset, clinical subtype or disease severity. PMID: 26871720
    7. Evidence showed lack of significant association between LILRA3 deletion and multiple sclerosis pathogenesis. [meta-analysis] PMID: 26274821
    8. LILRA3 is a new susceptibility factor for systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS). It predisposes to certain phenotypes such as leucopenia, thrombocytopenia, autoantibody positivity and increased disease activity. PMID: 24906639
    9. The current study was conducted to investigate the association of rs103294 of LILRA3 with benign prostatic hyperplasia risk. PMID: 23615473
    10. ILT6 deletion polymorphism does not appear to be a lupus susceptibility gene in South Indian Tamils, but may behave as a genetic modifier of autoantibody phenotype by influencing the production of anti-Ro60 and anti-Ro52 autoantibodies PMID: 24899637
    11. LILRA3 is an immunostimulatory molecule, whose deficiency is associated with higher frequency of B-non-Hodgkin's lymphoma. PMID: 24363809
    12. functional LILRA3 is a novel genetic risk factor for rheumatoid arthritis (RA), especially in males. It appears to highly predispose to ACPA-positive RA and confers an increased risk of disease severity in patients with early RA. PMID: 24757135
    13. Data did not indicate any association of LILRA3 deletion with multiple sclerosis (MS) susceptibility, however, patients negative for the deletion may begin to suffer from MS significantly earlier than patients who are positive. PMID: 23238213
    14. LILRA1 and LILRA3 generally display a greater binding preference for binding to HLA-C free heavy chain, particularly following removal of beta2-microglobulin by acid treatment. PMID: 21270408
    15. These results suggest that LILRA3 may play a role in chronic inflammatory conditions such as rheumatoid arthritis. PMID: 20595277
    16. A deletion of LILRA3 gene was found in a minority of British population PMID: 12651072
    17. Six alleles characterised, of which four will encode unique peptides, one of which is likely to directly influence ligand binding. PMID: 12750859
    18. Multiple sclerosis associates with LILRA3 deletion. PMID: 19421224
    19. ILT6 deficiency may be a genetic risk factor for Sjogren's syndrome. PMID: 19790059

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.
  • 数据库链接：

    HGNC: 6604

    OMIM: 604818

    KEGG: hsa:11026

    STRING: 9606.ENSP00000251390

    UniGene: Hs.113277