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LIN7B Antibody

  • 中文名称：
    LIN7B兔多克隆抗体
  • 货号：
    CSB-PA012964GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9HAP6
  • 基因名：
    LIN7B
  • 别名：
    hVeli2 antibody; hLin7B antibody; hVeli2 antibody; Lin 7 homolog B C elegans antibody; LIN 7B antibody; Lin 7b protein likely ortholog of mouse LIN 7B mammalian LIN 7 protein 2 antibody; Lin-7B antibody; LIN7B antibody; LIN7B_HUMAN antibody; MALS 2 antibody; MALS-2 antibody; MALS2 antibody; Mammalian lin seven protein 2 antibody; Mammalian lin-seven protein 2 antibody; Protein lin 7 homolog B antibody; Protein lin-7 homolog B antibody; VELI 2 antibody; Veli-2 antibody; VELI2 antibody; Vertebrate lin 7 homolog 2 antibody; Vertebrate lin-7 homolog 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LIN7B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface.
  • 基因功能参考文献：
    1. functional deficiency in Lin-7B could be implicated in clinical phenotypes in some autism spectrum disorders patients through bringing about abnormal cortical architecture PMID: 25196215
    2. Data suggest that decreased cortical LIN7b expression may contribute to abnormal corticostriatal connectivity in Huntington disease. PMID: 20720508
    3. LIN7B is a partner of IRSp53 anchoring the actin-based membrane cytoskeleton at cell-cell contacts. PMID: 14596909
    4. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current PMID: 15317815
    5. Lin-7B is a binding partner for Rhotekin in the human brain cDNA library PMID: 16979770

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction.
  • 蛋白家族：
    Lin-7 family
  • 数据库链接：

    HGNC: 17788

    OMIM: 612331

    KEGG: hsa:64130

    STRING: 9606.ENSP00000221459

    UniGene: Hs.221737