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  4. LNX1 Antibody

LNX1 Antibody

  • 货号：
    CSB-PA013022GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TBB1
  • 基因名：
    LNX1
  • 别名：
    LNX1 antibody; LNX antibody; PDZRN2 antibody; UNQ574/PRO1136 antibody; E3 ubiquitin-protein ligase LNX antibody; EC 2.3.2.27 antibody; Ligand of Numb-protein X 1 antibody; Numb-binding protein 1 antibody; PDZ domain-containing RING finger protein 2 antibody; RING-type E3 ubiquitin transferase LNX antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human LNX1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
  • 基因功能参考文献：
    1. study provided the evidences that LNX1 signaling plays important roles in regulating the stemness of colon cancer cells PMID: 29190716
    2. LNX was closely related to human gliomas and suggested it plays an important role in gliomas by notch signaling. PMID: 16324299
    3. LNX1-mediated ubiquitination and degradation of PBK inhibited cell proliferation and enhanced sensitivity to doxorubicin-induced apoptosis. PMID: 22889411
    4. identify and confirm six novel LNX1 binding partners: KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2 and PBK, and suggest that LNX1 functions as a signalling scaffold. PMID: 22087225
    5. The s found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever. PMID: 22066909
    6. LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis PMID: 22045731
    7. Down-regulation of LNX could result in cell cycle arrest in G0/G1 phase through inhibition of beta-catenin, MAPK, NFkappaB, c-Myc-dependent pathway and activation of p53, TGF-beta-dependent pathway. PMID: 21104141
    8. LNX and RhoC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1. PMID: 19701800
    9. identifed ligand of Numb protein X as an Np9-interacting partner; findings point to the possibility that Np9 affects tumorigenesis through the LNX/Numb/Notch pathway PMID: 15367597
    10. The presence of multiple protein binding domains involved in signal transduction and interaction with Numb and SKIP suggested an important role for LNX in tumorogenesis. PMID: 16002321
    11. The interaction of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src. PMID: 17936276
    12. Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas. PMID: 18940473
    13. A direct interaction between ErbB2 and mouse LNX1 was identified, suggesting that LNX1 may be involved in neuregulin-1/ErbB signaling in perisynaptic Schwann cells. PMID: 16122940
    14. The tyrosine phosphorylation of the LDNPAY sequence motif in mouse LNX could generate a binding site for the phosphorylation-dependent binding of other PTB domain-containing proteins. PMID: 9535908
    15. Describes various glioblastoma multiforms containing the amplicon on chromosomal segment 4q12, including the LNX1 gene. PMID: 17504929

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in heart, placenta, kidney, pancreas and brain.
  • 数据库链接：

    HGNC: 6657

    OMIM: 609732

    KEGG: hsa:84708

    STRING: 9606.ENSP00000263925

    UniGene: Hs.518760