LXN Antibody
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中文名称:LXN兔多克隆抗体
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货号:CSB-PA013240GA01HU
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规格:¥3,900
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其他:
产品详情
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Uniprot No.:Q9BS40
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基因名:LXN
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别名:ECI antibody; Endogenous carboxypeptidase inhibitor antibody; Latexin antibody; Latexin protein antibody; LXN antibody; LXN_HUMAN antibody; MUM antibody; Protein MUM antibody; TCI antibody; Tissue carboxypeptidase inhibitor antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Human LXN
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免疫原种属:Homo sapiens (Human)
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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产品提供形式:Liquid
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应用范围:ELISA,WB
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Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
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基因功能参考文献:
- Results identified that LXN expression inversely modulates taxane-chemoresistance in the PC-3 prostate cancer cell line. Inhibition of LXN expression in the bone microenvironment promotes chemoresistance, in part through a methylation-dependent mechanism. PMID: 28087740
- Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells. PMID: 26530530
- Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells. PMID: 25551472
- latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues. PMID: 24399246
- CD146 and Lxn increased tumor migration and invasion of thyroid cancer. PMID: 23712706
- The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma. PMID: 23364479
- These results are consistent with a tumor suppressor role for latexin. PMID: 23028717
- Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines. PMID: 21567403
- downregulated expression in gastric carcinomas; tumor suppressor PMID: 21466706
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亚细胞定位:Cytoplasm.
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蛋白家族:Protease inhibitor I47 (latexin) family
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组织特异性:Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.
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数据库链接:
HGNC: 13347
OMIM: 609305
KEGG: hsa:56925
STRING: 9606.ENSP00000264265
UniGene: Hs.478067
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