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MAEA Antibody

  • 货号：
    CSB-PA002337
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using Emp Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q7L5Y9
  • 基因名：
    MAEA
  • 别名：
    1110030D19Rik antibody; Cell proliferation inducing gene 5 protein antibody; Cell proliferation-inducing gene 5 protein antibody; EMLP antibody; EMP antibody; Erythroblast macrophage protein antibody; GID complex subunit 9 FYV10 homolog antibody; GID9 antibody; HLC 10 antibody; HLC-10 antibody; HLC10 antibody; Human lung cancer oncogene 10 protein antibody; Lung cancer related protein 10 antibody; Macrophage erythroblast attacher antibody; MAEA antibody; MAEA_HUMAN antibody; MGC93683 antibody; PIG5 antibody; Proliferation inducing gene 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Emp.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages. Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (Probable).
  • 基因功能参考文献：
    1. Emp expression correlates with erythroblastic island formation and has an important function for bone marrow hematopoiesis. PMID: 23566571
    2. These results suggest that Emp undergoes dynamic rearrangements within the nuclear architecture that are correlated with cell division. PMID: 16510120
    3. RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells. PMID: 17467196
  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Detected at macrophage membranes (at protein level). Ubiquitous.
  • 数据库链接：

    HGNC: 13731

    OMIM: 606801

    KEGG: hsa:10296

    STRING: 9606.ENSP00000302830

    UniGene: Hs.139896