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MAEA Antibody

  • 货号：
    CSB-PA013310LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate
      All lanes: MAEA antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46, 41, 37, 27 kDa
      Observed band size: 46 kDa
    • IHC image of CSB-PA013310LA01HU diluted at 1:600 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA013310LA01HU diluted at 1:600 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescent analysis of Hela cells using CSB-PA013310LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAEA Polyclonal antibody
  • Uniprot No.：
    Q7L5Y9
  • 基因名：
    MAEA
  • 别名：
    1110030D19Rik antibody; Cell proliferation inducing gene 5 protein antibody; Cell proliferation-inducing gene 5 protein antibody; EMLP antibody; EMP antibody; Erythroblast macrophage protein antibody; GID complex subunit 9 FYV10 homolog antibody; GID9 antibody; HLC 10 antibody; HLC-10 antibody; HLC10 antibody; Human lung cancer oncogene 10 protein antibody; Lung cancer related protein 10 antibody; Macrophage erythroblast attacher antibody; MAEA antibody; MAEA_HUMAN antibody; MGC93683 antibody; PIG5 antibody; Proliferation inducing gene 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Macrophage erythroblast attacher protein (299-356AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MAEA Antibody (CSB-PA013310LA01HU)，的标记方式是Non-conjugated。对于MAEA Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013310LB01HU MAEA Antibody, HRP conjugated ELISA
    FITC CSB-PA013310LC01HU MAEA Antibody, FITC conjugated
    Biotin CSB-PA013310LD01HU MAEA Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages. Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (Probable).
  • 基因功能参考文献：
    1. Emp expression correlates with erythroblastic island formation and has an important function for bone marrow hematopoiesis. PMID: 23566571
    2. These results suggest that Emp undergoes dynamic rearrangements within the nuclear architecture that are correlated with cell division. PMID: 16510120
    3. RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells. PMID: 17467196
  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Detected at macrophage membranes (at protein level). Ubiquitous.
  • 数据库链接：

    HGNC: 13731

    OMIM: 606801

    KEGG: hsa:10296

    STRING: 9606.ENSP00000302830

    UniGene: Hs.139896