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MAT2B Antibody

  • 货号：
    CSB-PA882157LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA882157LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Rat heart tissue
      All lanes: MAT2B antibody at 4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38, 37, 29, 35, 10 kDa
      Observed band size: 38 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MAT2B Polyclonal antibody
  • Uniprot No.：
    Q9NZL9
  • 基因名：
  • 别名：
    1110064C04Rik antibody; 2410018D16Rik antibody; AI182287 antibody; AU022853 antibody; Beta regulatory subunit of methionine adenosyltransferase antibody; dTDP 4 keto 6 deoxy D glucose 4 reductase antibody; DTDP-4-keto-6-deoxy-D-glucose 4-reductase antibody; MAT II antibody; MAT II beta antibody; Mat2b antibody; MAT2B_HUMAN antibody; MATIIbeta antibody; Methionine adenosyltransferase 2 beta subunit antibody; Methionine adenosyltransferase 2 subunit beta antibody; Methionine adenosyltransferase II beta antibody; MGC12237 antibody; MSTP045 antibody; Nbla02999 antibody; OTTMUSP00000005600 antibody; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase antibody; Putative protein product of Nbla02999 antibody; RP23-382C18.2 antibody; SDR23E1 antibody; Short chain dehydrogenase/reductase family 23E member 1 antibody; TGR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Methionine adenosyltransferase 2 subunit beta protein (85-143AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MAT2B Antibody (CSB-PA882157LA01HU)，的标记方式是Non-conjugated。对于MAT2B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA882157LB01HU MAT2B Antibody, HRP conjugated ELISA
    FITC CSB-PA882157LC01HU MAT2B Antibody, FITC conjugated
    Biotin CSB-PA882157LD01HU MAT2B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:2000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).
  • 基因功能参考文献：
    1. Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity. PMID: 27573889
    2. Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf/MEK/ERK pathway PMID: 25794709
    3. Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation. PMID: 25294683
    4. MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis. PMID: 23325601
    5. The structure of MAT2B reveals a short-chain dehydrogenase/reductase (SDR) core with specificity for the NADP/H cofactor, and harbors the SDR catalytic triad. PMID: 23425511
    6. Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity. PMID: 21813468
    7. Data show MAT2beta variants reside mostly in the nucleus and regulate HuR subcellular content to affect cell proliferation. PMID: 20421296
    8. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells. PMID: 18041713
    9. Splicing variants of MAT2beta are up-regulated in hepatocellular carcinoma and regulated tumor cell growth and death. PMID: 18045590
    10. a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B PMID: 18698677
    11. differences in malignant cell survival, effected by MAT-IIbeta ablation, suggest that it may be possible to use this approach to disadvantage leukemic cell survival in vivo with little to no harm to normal cells. PMID: 18753136

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  • 蛋白家族：
    DTDP-4-dehydrorhamnose reductase family, MAT2B subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 6905

    OMIM: 605527

    KEGG: hsa:27430

    STRING: 9606.ENSP00000325425

    UniGene: Hs.54642