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  4. MED15 Antibody

MED15 Antibody

  • 货号：
    CSB-PA267854
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA267854(MED15 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q96RN5
  • 基因名：
    MED15
  • 别名：
    MED15 antibody; ARC105 antibody; CTG7A antibody; PCQAP antibody; TIG1 antibody; TNRC7 antibody; Mediator of RNA polymerase II transcription subunit 15 antibody; Activator-recruited cofactor 105 kDa component antibody; ARC105 antibody; CTG repeat protein 7a antibody; Mediator complex subunit 15 antibody; Positive cofactor 2 glutamine/Q-rich-associated protein antibody; PC2 glutamine/Q-rich-associated protein antibody; TPA-inducible gene 1 protein antibody; TIG-1 antibody; Trinucleotide repeat-containing gene 7 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human MED15
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
  • 基因功能参考文献：
    1. MED15 does seem to play a tumour promoting role in the progression and metastatic spread of renal cell carcinoma PMID: 29400661
    2. MED15 overexpression arises during androgen deprivation therapy via hyper-activation of PI3K/Akt/mTOR signaling pathway in prostate cancer cells. PMID: 27974704
    3. MED15 as a potential biomarker for head and neck squamous cell carcinoma PMID: 26457685
    4. MED15 is differentially expressed in tumor-free testis and testicular germ cell tumors PMID: 26377566
    5. MED15 overexpression is a clonal event during head and neck squamous cell carcinoma progression. PMID: 25791637
    6. these findings implicate MED15 in CRPC, and as MED15 is evolutionary conserved, it is likely to emerge as a lethal phenotype in other therapeutic-resistant diseases, and not restricted to our disease model. PMID: 24374838
    7. MED15 and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 protein misfolding and proteotoxicity in vitro and in vivo. PMID: 22916034
    8. The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation. PMID: 20025940
    9. Methylation of TIG1 in prostatic neoplasms correlates with methylation of the retinoic acid receptor beta gene. PMID: 14691453
    10. Limited role of exon 7 PCQAP polymorphisms in the pathogenesis of schizophrenia. PMID: 15318033
    11. TIG1 gene Silencing by promoter hypermethylation is associated with nasopharyngeal carcinoma PMID: 15455391
    12. SREBPs use the evolutionarily conserved ARC105 (also called MED15) subunit to activate target genes PMID: 16799563
    13. results suggest that TRIM11, with the ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta signaling PMID: 16904669
    14. The protein encoded by this gene was identified as ARC105, a 105kDa component of the Activator-Recruited Cofactor (ARC) that is involved in mediating gene activation by several classes of transcriptional regulators. PMID: 10235267

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Mediator complex subunit 15 family
  • 组织特异性：
    Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and k
  • 数据库链接：

    HGNC: 14248

    OMIM: 607372

    KEGG: hsa:51586

    STRING: 9606.ENSP00000263205

    UniGene: Hs.517421