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MID2 Antibody

  • 货号：
    CSB-PA892324ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA892324ESR2HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA892324ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MID2 Polyclonal antibody
  • Uniprot No.：
    Q9UJV3
  • 基因名：
    MID2
  • 别名：
    FLJ37715 antibody; FLJ41813 antibody; FXY2 antibody; MID2 antibody; Midin 2 antibody; Midin-2 antibody; Midline 2 antibody; Midline defect 2 antibody; Midline-2 antibody; probable E3 ubiquitin protein ligase MID2 antibody; Probable E3 ubiquitin-protein ligase MID2 antibody; RING finger protein 60 antibody; Ring finger protein protein 60 antibody; RNF60 antibody; TRIM1 antibody; TRIM1_HUMAN antibody; tripartite motif containing protein 1 antibody; Tripartite motif protein 1 antibody; Tripartite motif-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Probable E3 ubiquitin-protein ligase MID2 protein (506-735AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in microtubule stabilization.
  • 基因功能参考文献：
    1. overexpressed in advanced breast cancer and high overexpression is prognostic factor for poor overall survival PMID: 26791755
    2. Mid2 regulates cell division through the ubiquitination of astrin on K409, which is critical for its degradation and proper cytokinesis. PMID: 26748699
    3. A novel missense mutation (c.1040G>A, p.Arg347Gln) was reported in MID2, which encodes ubiquitin ligase E3, as the likely cause of X-linked mental retardation in a large kindred. PMID: 24115387
    4. MID2 coiled-coil motifs mediate both homo- and heterodimerization, a prerequisite for association of the MID-alpha 4 complex with microtubules. PMID: 11806752
    5. MID2 is a candidate gene for FG syndrome. PMID: 16283679

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  • 相关疾病：
    Mental retardation, X-linked 101 (MRX101)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.
  • 数据库链接：

    HGNC: 7096

    OMIM: 300204

    KEGG: hsa:11043

    STRING: 9606.ENSP00000262843

    UniGene: Hs.12256