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  4. Recombinant Human Probable E3 ubiquitin-protein ligase MID2 (MID2)

Recombinant Human Probable E3 ubiquitin-protein ligase MID2 (MID2)

  • 中文名称：
    人MID2重组蛋白
  • 货号：
    CSB-YP892324HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MID2重组蛋白
  • 货号：
    CSB-EP892324HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MID2重组蛋白
  • 货号：
    CSB-EP892324HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MID2重组蛋白
  • 货号：
    CSB-BP892324HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MID2重组蛋白
  • 货号：
    CSB-MP892324HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MID2
  • Uniprot No.：
  • 别名：
    FLJ37715; FLJ41813; FXY2; MID2; Midin 2; Midin-2; Midline 2; Midline defect 2; Midline-2; probable E3 ubiquitin protein ligase MID2; Probable E3 ubiquitin-protein ligase MID2; RING finger protein 60; Ring finger protein protein 60; RNF60; TRIM1; TRIM1_HUMAN; tripartite motif containing protein 1; Tripartite motif protein 1; Tripartite motif-containing protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-735
  • 氨基酸序列
    MGESPASVVL NASGGLFSLK METLESELTC PICLELFEDP LLLPCAHSLC FSCAHRILVS SCSSGESIEP ITAFQCPTCR YVISLNHRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSES RRERTYRPTT AMSSERIACQ FCEQDPPRDA VKTCITCEVS YCDRCLRATH PNKKPFTSHR LVEPVPDTHL RGITCLDHEN EKVNMYCVSD DQLICALCKL VGRHRDHQVA SLNDRFEKLK QTLEMNLTNL VKRNSELENQ MAKLIQICQQ VEVNTAMHEA KLMEECDELV EIIQQRKQMI AVKIKETKVM KLRKLAQQVA NCRQCLERST VLINQAEHIL KENDQARFLQ SAKNIAERVA MATASSQVLI PDINFNDAFE NFALDFSREK KLLEGLDYLT APNPPSIREE LCTASHDTIT VHWISDDEFS ISSYELQYTI FTGQANFISK SWCSWGLWPE IRKCKEAVSC SRLAGAPRGL YNSVDSWMIV PNIKQNHYTV HGLQSGTRYI FIVKAINQAG SRNSEPTRLK TNSQPFKLDP KMTHKKLKIS NDGLQMEKDE SSLKKSHTPE RFSGTGCYGA AGNIFIDSGC HYWEVVMGSS TWYAIGIAYK SAPKNEWIGK NASSWVFSRC NSNFVVRHNN KEMLVDVPPH LKRLGVLLDY DNNMLSFYDP ANSLHLHTFD VTFILPVCPT FTIWNKSLMI LSGLPAPDFI DYPERQECNC RPQESPYVSG MKTCH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in microtubule stabilization.
  • 基因功能参考文献：
    1. overexpressed in advanced breast cancer and high overexpression is prognostic factor for poor overall survival PMID: 26791755
    2. Mid2 regulates cell division through the ubiquitination of astrin on K409, which is critical for its degradation and proper cytokinesis. PMID: 26748699
    3. A novel missense mutation (c.1040G>A, p.Arg347Gln) was reported in MID2, which encodes ubiquitin ligase E3, as the likely cause of X-linked mental retardation in a large kindred. PMID: 24115387
    4. MID2 coiled-coil motifs mediate both homo- and heterodimerization, a prerequisite for association of the MID-alpha 4 complex with microtubules. PMID: 11806752
    5. MID2 is a candidate gene for FG syndrome. PMID: 16283679

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  • 相关疾病：
    Mental retardation, X-linked 101 (MRX101)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.
  • 数据库链接：

    HGNC: 7096

    OMIM: 300204

    KEGG: hsa:11043

    STRING: 9606.ENSP00000262843

    UniGene: Hs.12256