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MMP24 Antibody

  • 中文名称：
    MMP24兔多克隆抗体
  • 货号：
    CSB-PA166201
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using CSB-PA166201(MMP24 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y5R2
  • 基因名：
    MMP24
  • 别名：
    Matrix metallopeptidase 24 (membrane inserted) antibody; Matrix metallopeptidase 24 antibody; Membrane type 5 matrix metalloproteinase antibody; Membrane type matrix metalloproteinase 5 antibody; Membrane-type matrix metalloproteinase 5 antibody; Membrane-type-5 matrix metalloproteinase antibody; MMP 24 antibody; MMP 25 antibody; MMP-24 antibody; Mmp24 antibody; MMP24_HUMAN antibody; MMP25 antibody; MT MMP5 antibody; MT-MMP 5 antibody; MT5 MMP antibody; MT5-MMP antibody; MT5MMP antibody; MTMMP5 antibody; Processed matrix metalloproteinase-24 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human MMP24
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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靶点详情

  • 功能：
    Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin.
  • 基因功能参考文献：
    1. MMP24 overexpression is associated with lung cancer metastasis. PMID: 27869830
    2. Polymorphisms in MAP3K3, MMP24 and IGF1R are associated with greater height and act additively on height in children of an admixed population. PMID: 26304632
    3. In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis. PMID: 24669030
    4. MMP-24 gene silencing by RNAi can suppress the invasiveness of ovarian cancer SKOV(3) cells in vitro. PMID: 19403421
    5. down-regulation of most MT-MMPs is typical for prostate carcinoma; seems to occur mainly in epithelial cells PMID: 12661033
    6. MT5-MMP retrieval to the plasma membrane is regulated by Mint-3 by binding to its carboxyl end motif EWV PMID: 14990567
    7. MT5-MMP is expressed in normal human endometrium and there is enhanced exprestion in endometrium from patients with entometriosis with strongest signal in epithelial cells. PMID: 17952761
    8. These results suggest more than one human MT5-MMP transcript may exist in the central nervous system. PMID: 18062926

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  • 亚细胞定位：
    [Matrix metalloproteinase-24]: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.; [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas.
  • 数据库链接：

    HGNC: 7172

    OMIM: 604871

    KEGG: hsa:10893

    STRING: 9606.ENSP00000246186

    UniGene: Hs.715494