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MOK Antibody

  • 货号：
    CSB-PA003933
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using RAGE Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UQ07
  • 基因名：
    MOK
  • 别名：
    Antigen recognized by autologous cytolytic T lymphocytes antibody; EC 2.7.11.22 antibody; LE 9211 A antigen antibody; MAPK/MAK/MRK overlapping kinase antibody; MOK antibody; MOK protein kinase antibody; MOK_HUMAN antibody; RAGE 1 antibody; RAGE antibody; RAGE-1 antibody; RAGE1 antibody; Renal cell carcinoma antigen (MOK protein kinase) antibody; Renal tumor antigen 1 antibody; Renal tumor antigen antibody; STK30 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RAGE.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
  • 基因功能参考文献：
    1. our results suggest MOK promoter hypomethylation is a common event and contributes to MOK overexpression in acute myeloid leukemia PMID: 25755699
    2. The findings indicate a statistically significant association of p.Gly82Ser polymorphism in RAGE with DR in T2DM patients. PMID: 24529564
    3. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
    4. Our results suggest that RAGE may be important in tumor invasion and could be a potential predictor for the prognosis of hepatocellular carcinoma patients. PMID: 21717246
    5. PBMNC from type 2 diabetics were more sensitive to innate immune stimulation with LPS and monoclonal agonist anti-TLR4 than were cells from ND. The actions of LPS, anti-TLR4 and anti-RAGE potentiated the production of IL-6 and TNF-alpha in both groups. PMID: 21377387
    6. The RAGE pathway may play an important role in STAT3 induction in glioma-associated macrophages and microglia, a process that may be mediated through S100B. PMID: 21264954
    7. RAGE was demonstrated in all 8 yolk sac tumors and 21 of 26 embryonal carcinomas. In yolk sac tumors, RAGE reactivity was diffusely present throughout the tumors. In embryonal carcinomas, RAGE was identified only in yolk sac components PMID: 12777992
    8. identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2 PMID: 15327990
    9. May provide suitable targets for immunotherapy of renal cell carcinoma. PMID: 15900605
    10. Compared RAGE and PAX-2 staining in metastatic clear renal cell carcinoma. PMID: 18685487
    11. POLL is under genetic selection in Sub-Saharan African populations. PMID: 19060005

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  • 亚细胞定位：
    Cytoplasm. Cell projection, cilium. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 组织特异性：
    Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
  • 数据库链接：

    HGNC: 9833

    OMIM: 605762

    KEGG: hsa:5891

    STRING: 9606.ENSP00000355304

    UniGene: Hs.104119