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  4. Recombinant Human MAPK/MAK/MRK overlapping kinase (MOK)

Recombinant Human MAPK/MAK/MRK overlapping kinase (MOK)

  • 中文名称：
    人MOK重组蛋白
  • 货号：
    CSB-YP891576HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MOK重组蛋白
  • 货号：
    CSB-EP891576HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MOK重组蛋白
  • 货号：
    CSB-EP891576HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MOK重组蛋白
  • 货号：
    CSB-BP891576HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MOK重组蛋白
  • 货号：
    CSB-MP891576HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MOK
  • Uniprot No.：
  • 别名：
    Antigen recognized by autologous cytolytic T lymphocytes; EC 2.7.11.22; LE 9211 A antigen; MAPK/MAK/MRK overlapping kinase; MOK; MOK protein kinase; MOK_HUMAN; RAGE 1; RAGE; RAGE-1; RAGE1; Renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; Renal tumor antigen; STK30
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-419
  • 氨基酸序列
    MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE IQALRRLNPH PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL SEKKIMHYMY QLCKSLDHIH RNGIFHRDVK PENILIKQDV LKLGDFGSCR SVYSKQPYTE YISTRWYRAP ECLLTDGFYT YKMDLWSAGC VFYEIASLQP LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP FKKGSGIPLL TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP KLKLSGVVRL SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD LKPAPQQCRL PTIVRKGGR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
  • 基因功能参考文献：
    1. our results suggest MOK promoter hypomethylation is a common event and contributes to MOK overexpression in acute myeloid leukemia PMID: 25755699
    2. The findings indicate a statistically significant association of p.Gly82Ser polymorphism in RAGE with DR in T2DM patients. PMID: 24529564
    3. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
    4. Our results suggest that RAGE may be important in tumor invasion and could be a potential predictor for the prognosis of hepatocellular carcinoma patients. PMID: 21717246
    5. PBMNC from type 2 diabetics were more sensitive to innate immune stimulation with LPS and monoclonal agonist anti-TLR4 than were cells from ND. The actions of LPS, anti-TLR4 and anti-RAGE potentiated the production of IL-6 and TNF-alpha in both groups. PMID: 21377387
    6. The RAGE pathway may play an important role in STAT3 induction in glioma-associated macrophages and microglia, a process that may be mediated through S100B. PMID: 21264954
    7. RAGE was demonstrated in all 8 yolk sac tumors and 21 of 26 embryonal carcinomas. In yolk sac tumors, RAGE reactivity was diffusely present throughout the tumors. In embryonal carcinomas, RAGE was identified only in yolk sac components PMID: 12777992
    8. identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2 PMID: 15327990
    9. May provide suitable targets for immunotherapy of renal cell carcinoma. PMID: 15900605
    10. Compared RAGE and PAX-2 staining in metastatic clear renal cell carcinoma. PMID: 18685487
    11. POLL is under genetic selection in Sub-Saharan African populations. PMID: 19060005

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  • 亚细胞定位：
    Cytoplasm. Cell projection, cilium. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 组织特异性：
    Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
  • 数据库链接：

    HGNC: 9833

    OMIM: 605762

    KEGG: hsa:5891

    STRING: 9606.ENSP00000355304

    UniGene: Hs.104119